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    scyl1 SCY1-like, kinase-like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 793792, updated on 2-Nov-2024

    Summary

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    Official Symbol
    scyl1provided by ZNC
    Official Full Name
    SCY1-like, kinase-like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8915
    See related
    Ensembl:ENSDARG00000079854 AllianceGenome:ZFIN:ZDB-GENE-030131-8915
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk36e11; wu:fk36e11; si:ch211-276i12.7
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 21. Orthologous to human SCYL1 (SCY1 like pseudokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See scyl1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (45575049..45595732, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (46587748..46608446, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor responder 3 Neighboring gene retinoic acid receptor responder 3-like Neighboring gene si:ch211-276i12.9 Neighboring gene zgc:194285 Neighboring gene si:ch211-276i12.4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression and function of lncRNA MALAT-1 in the embryonic development of zebrafish. Wu M, et al. Gene, 2019 Jan 5. PMID 30248354
    2. Identification of Potential Long Noncoding RNA Biomarker of Mercury Compounds in Zebrafish Embryos. Cao M, et al. Chem Res Toxicol, 2019 May 20. PMID 30912647
    3. Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. Madera D, et al. Int J Mol Sci, 2023 Dec 19. PMID 38203224, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-terminal kinase-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      45575049..45595732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001332472.7 → XP_001332508.1  N-terminal kinase-like protein

      UniProtKB/TrEMBL
      A0A8M1Q6V7, E7F3D6
      Related
      ENSDARP00000068527.3, ENSDART00000074038.5
      Conserved Domains (3) summary
      pfam02985
      Location:504 → 534
      HEAT; HEAT repeat
      sd00044
      Location:348 → 369
      HEAT; HEAT repeat [structural motif]
      cl21453
      Location:28 → 293
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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