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    ddx39aa DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa [ Danio rerio (zebrafish) ]

    Gene ID: 325550, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ddx39aaprovided by ZNC
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4275
    See related
    Ensembl:ENSDARG00000006225 AllianceGenome:ZFIN:ZDB-GENE-030131-4275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ddx39a; zgc:55881; wu:fc87b12
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in mRNA export from nucleus and mRNA splicing, via spliceosome. Orthologous to human DDX39A (DExD-box helicase 39A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ddx39aa in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (45205920..45215284, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (44504617..44513981, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene novel protein containing SEA domains Neighboring gene novel protein containing SEA domains Neighboring gene zgc:111983 Neighboring gene ecotropic viral integration site 5 like Neighboring gene uncharacterized LOC110439860

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic profile of early zebrafish PGCs by single cell sequencing. Zhang X, et al. PLoS One, 2019. PMID 31412047, Free PMC Article
    2. Processing of fish Ig heavy chain transcripts: diverse splicing patterns and unusual nonsense mediated decay. Quiniou SM, et al. Dev Comp Immunol, 2011 Sep. PMID 21168434
    3. The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish. Zhang L, et al. Development, 2018 Apr 23. PMID 29636379
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 39a
    Eukaryotic initiation factor 4a
    NP_001315271.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328342.1 → NP_001315271.1  DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa

      Status: VALIDATED

      Source sequence(s)
      EH433199, EH444410, EH559791, EH570750
      UniProtKB/TrEMBL
      A0A8M1P8Z3, A2AWA1
      Related
      ENSDARP00000008513.6, ENSDART00000014727.8
      Conserved Domains (3) summary
      PTZ00424
      Location:19 → 417
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:263 → 389
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:46 → 249
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      45205920..45215284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199721.1: Suppressed sequence

      Description
      NM_199721.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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