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    gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a [ Danio rerio (zebrafish) ]

    Gene ID: 393760, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gnao1aprovided by ZNC
    Official Full Name
    guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1757
    See related
    Ensembl:ENSDARG00000016676 AllianceGenome:ZFIN:ZDB-GENE-040426-1757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gnao1; zgc:73315; wu:fq26h05
    Summary
    Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway and adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in bone tissue; gill; nervous system; neural rod; and trigeminal placode. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gnao1a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (22793401..22976664)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (22804071..22987598)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 21 Neighboring gene heat shock transcription factor 4 Neighboring gene uncharacterized LOC108179979 Neighboring gene core-binding factor subunit beta Neighboring gene uncharacterized LOC137488280

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation. Schneider PN, et al. PLoS One, 2012. PMID 22957046, Free PMC Article
    2. Effects of chronic ethanol administration on brain protein levels: a proteomic investigation using 2-D DIGE system. Damodaran S, et al. Eur J Pharmacol, 2006 Oct 10. PMID 16978605
    3. Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity. Chen L, et al. Environ Sci Technol, 2017 Feb 7. PMID 28026967
    4. Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish. Teoh SL, et al. J Chem Neuroanat, 2015 Dec. PMID 26571427
    5. Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Taylor R, et al. Nat Commun, 2022 Nov 22. PMID 36414621, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73315

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables corticotropin-releasing hormone receptor 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mu-type opioid receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
    Names
    Galpha o1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200787.2 → NP_957081.1  guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a

      See identical proteins and their annotated locations for NP_957081.1

      Status: VALIDATED

      Source sequence(s)
      BX001001, BX088710, BX663522
      UniProtKB/TrEMBL
      A0A8M1PFR7, Q6PBP1
      Related
      ENSDARP00000124476.1, ENSDART00000149685.3
      Conserved Domains (1) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      22793401..22976664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159069.5 → XP_005159126.1  guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B616, F8W442
      Related
      ENSDARP00000124253.1, ENSDART00000150106.3
      Conserved Domains (2) summary
      cd00066
      Location:34 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:14 → 352
      G_alpha; G protein alpha subunit

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395026.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      38217..167354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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