bcl2l1 BCL2 like 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bcl2l1provided by ZNC
Official Full Name: BCL2 like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010730-1
See related: Ensembl:ENSDARG00000008434 AllianceGenome:ZFIN:ZDB-GENE-010730-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: blp1; bcl2l; cb1021; zfBLP1
Summary: Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Acts upstream of or within negative regulation of apoptotic process; thyroid gland development; and tissue homeostasis. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including blood island; endocrine system; extension; immune system; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (18953687..18982415, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (19027053..19056258, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The bcl2l gene operates in the inhibition of cell death under direct regulation of a thyroid specific set of transcription factors
Title: Zebrafish bcl2l is a survival factor in thyroid development.
Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
Title: Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
Delta113p53 functions to antagonize p53-induced apoptosis via activating bcl2L
Title: p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish.
Bcl-xL can block post-apoptotic necrosis processes thereby rescuing betanodavirus-infected cells
Title: Zebrafish anti-apoptotic protein zfBcl-xL can block betanodavirus protein alpha-induced mitochondria-mediated secondary necrosis cell death.
transgenic overexpression of zfBLP1 or myeloid cell leukemia sequence 1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Title: Imbalance in liver homeostasis leading to hyperplasia by overexpressing either one of the Bcl-2-related genes, zfBLP1 and zfMcl-1a.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within thyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bcl-2-like protein 1

Names: Bcl-xL-like protein 1; bcl-XL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131807.1 → NP_571882.1 bcl-2-like protein 1

See identical proteins and their annotated locations for NP_571882.1

Status: PROVISIONAL

Source sequence(s)

AF317837

UniProtKB/TrEMBL

B2GRK1, F6PFD0, Q90Z98

Related

ENSDARP00000119990.1, ENSDART00000147617.3

Conserved Domains (3) summary

cd06845
Location:75 → 196

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 234

bcl-2; apoptosis regulator

pfam02180
Location:2 → 26

BH4; Bcl-2 homology region 4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007134.7 Reference GRCz11 Primary Assembly

Range

18953687..18982415 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005162026.5 → XP_005162083.1 bcl-2-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_005162083.1

UniProtKB/TrEMBL

B2GRK1, F6PFD0, Q90Z98

Related

ENSDARP00000027919.6, ENSDART00000012507.8

Conserved Domains (3) summary

cd06845
Location:75 → 196

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 234

bcl-2; apoptosis regulator

pfam02180
Location:2 → 26

BH4; Bcl-2 homology region 4