epoa erythropoietin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: epoaprovided by ZNC
Official Full Name: erythropoietin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061218-3
See related: Ensembl:ENSDARG00000055163 AllianceGenome:ZFIN:ZDB-GENE-061218-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: epo
Summary: Predicted to enable cytokine activity. Acts upstream of or within nucleate erythrocyte development; pronephros development; and response to activity. Located in perinuclear region of cytoplasm. Is expressed in several structures, including brain; digestive system; eye; heart; and immune system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (21891252..21918393, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (21624135..21652055, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zebrafish epo cDNA was cloned and the expression of zepo mRNA was mainly in the heart and liver.
Title: The zebrafish erythropoietin: functional identification and biochemical characterization.
characterization of zebrafish epo and epor demonstrates the conservation of an ancient program that ensures proper red blood cell numbers during normal homeostasis and under hypoxic conditions
Title: Functional conservation of erythropoietin signaling in zebrafish.

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General gene information

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Markers

A005S32 (e-PCR)
- UniSTS:17817

G41731 (e-PCR)
- UniSTS:19704

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables erythropoietin receptor binding	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within erythrocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleate erythrocyte development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleate erythrocyte development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: erythropoietin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.