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    slc30a1a solute carrier family 30 member 1a [ Danio rerio (zebrafish) ]

    Gene ID: 393853, updated on 14-Nov-2024

    Summary

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    Official Symbol
    slc30a1aprovided by ZNC
    Official Full Name
    solute carrier family 30 member 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1840
    See related
    Ensembl:ENSDARG00000005463 AllianceGenome:ZFIN:ZDB-GENE-040426-1840
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slc30a1; zgc:77589
    Summary
    Predicted to enable calcium channel inhibitor activity and zinc ion transmembrane transporter activity. Acts upstream of or within response to zinc ion. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in central nervous system; hatching gland; and yolk syncytial layer. Orthologous to human SLC30A1 (solute carrier family 30 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slc30a1a in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (13894076..13913790)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (13998112..14017810)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene NIMA-related kinase 2 Neighboring gene si:dkey-249p7.4 Neighboring gene retinal degeneration 3, GUCY2D regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish Znt1a(sa17) mutant reveals roles of zinc transporter-1a in embryonic development. Muraina IA, et al. J Trace Elem Med Biol, 2020 Jul. PMID 32199393
    2. Cadmium-induced ovarian pathophysiology is mediated by change in gene expression pattern of zinc transporters in zebrafish (Danio rerio). Chouchene L, et al. Chem Biol Interact, 2011 Sep 5. PMID 21756885
    3. Localized Infections with P. aeruginosa Strains Defective in Zinc Uptake Reveal That Zebrafish Embryos Recapitulate Nutritional Immunity Responses of Higher Eukaryotes. Secli V, et al. Int J Mol Sci, 2023 Jan 4. PMID 36674459, Free PMC Article
    4. Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate, zinc sulfate and quantum dots. Tang S, et al. Metallomics, 2013 Oct. PMID 23912858
    5. Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a. Muraina IA, et al. Biochem Biophys Res Commun, 2020 Aug 6. PMID 32517868

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a.
      Title: Hatching gland development and hatching in zebrafish embryos: A role for zinc and its transporters Zip10 and Znt1a.
    2. Downregulation of ZnT1 as well as the overexpression of ZIP10, in responses to the ovarian Zn depletion induced by Cd, play a major role in Cd accumulation and consequently in its reproductive toxicity.
      Title: Cadmium-induced ovarian pathophysiology is mediated by change in gene expression pattern of zinc transporters in zebrafish (Danio rerio).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77589

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to zinc ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within zinc ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc transporter 1a
    Names
    ZnT1
    solute carrier family 30 (zinc transporter), member 1
    solute carrier family 30 (zinc transporter), member 1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200879.1 → NP_957173.1  zinc transporter 1a

      See identical proteins and their annotated locations for NP_957173.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063939
      UniProtKB/TrEMBL
      A0A8M1PF72, Q6P3M0
      Related
      ENSDARP00000022487.4, ENSDART00000007744.5
      Conserved Domains (2) summary
      COG1230
      Location:5 → 411
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:19 → 118
      Cation_efflux; Cation efflux family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      13894076..13913790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160431.5 → XP_005160488.1  zinc transporter 1a isoform X1

      UniProtKB/TrEMBL
      A0A8M2B789
      Conserved Domains (2) summary
      COG1230
      Location:5 → 414
      CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
      pfam01545
      Location:19 → 118
      Cation_efflux; Cation efflux family
    Nucleotide Protein Strain
    Heading Accession and Version

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