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    hsd11b2 hydroxysteroid (11-beta) dehydrogenase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 334098, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hsd11b2provided by ZNC
    Official Full Name
    hydroxysteroid (11-beta) dehydrogenase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6030
    See related
    Ensembl:ENSDARG00000001975 AllianceGenome:ZFIN:ZDB-GENE-030131-6030
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    11-DH2; wu:fi31d01
    Summary
    Enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity. Acts upstream of or within cortisol metabolic process and multicellular organismal response to stress. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including brain; cardiovascular system; digestive system; endocrine system; and eye. Human ortholog(s) of this gene implicated in apparent mineralocorticoid excess syndrome; hypertension; inherited metabolic disorder; obesity; and type 1 diabetes mellitus. Orthologous to human HSD11B2 (hydroxysteroid 11-beta dehydrogenase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hsd11b2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (35112052..35126343, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (34840575..34854866, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene agouti related neuropeptide Neighboring gene zinc finger DHHC-type containing 1 Neighboring gene tubulin polymerization-promoting protein family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Maternal stress-associated cortisol stimulation may protect embryos from cortisol excess in zebrafish. Faught E, et al. R Soc Open Sci, 2016 Feb. PMID 26998341, Free PMC Article
    2. Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults. Theodoridi A, et al. Int J Mol Sci, 2021 Nov 20. PMID 34830405, Free PMC Article
    3. Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole. Inderbinen SG, et al. Toxicol Appl Pharmacol, 2021 Feb 1. PMID 33387577
    4. Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins. Meyer A, et al. Toxicology, 2012 Nov 15. PMID 22796344
    5. Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type 2 enzyme in the zebrafish. Mindnich R, et al. J Steroid Biochem Mol Biol, 2007 Jan. PMID 17085046

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults.
      Title: Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults.
    2. Our experiments show that 20b-HSD type 2, together with 11b-HSD type 2, represents a short pathway in zebrafish to rapidly inactivate and excrete cortisol. Therefore, 20beta-HSD type 2 is an important enzyme in stress response
      Title: Zebrafish 20β-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response.
    3. Sequence comparison revealed the presence of an alanine at position 253 on zebrafish 11beta-HSD2, corresponding to cysteine-264 in the substratebinding pocket of the human enzyme
      Title: Species-specific differences in the inhibition of human and zebrafish 11β-hydroxysteroid dehydrogenase 2 by thiram and organotins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 11-beta-hydroxysteroid dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 11-beta-hydroxysteroid dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cortisol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cortisol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucocorticoid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organismal response to stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    11-beta-hydroxysteroid dehydrogenase type 2
    Names
    11-HSD type II
    11-beta-HSD type II
    11-beta-HSD2
    11-beta-hydroxysteroid dehydrogenase type II
    NAD-dependent 11-beta-hydroxysteroid dehydrogenase
    corticosteroid 11-beta-dehydrogenase isozyme 2
    NP_997885.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212720.2 → NP_997885.2  11-beta-hydroxysteroid dehydrogenase type 2

      Status: PROVISIONAL

      Source sequence(s)
      BC065613
      UniProtKB/Swiss-Prot
      F1QLP1, Q6P0H9
      Related
      ENSDARP00000118501.1, ENSDART00000141211.2
      Conserved Domains (2) summary
      cd09805
      Location:86 → 366
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:86 → 279
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      35112052..35126343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QLP1.1 GenPept UniProtKB/Swiss-Prot:F1QLP1

    Gene LinkOut

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