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    dcun1d2a DCN1, defective in cullin neddylation 1, domain containing 2a [ Danio rerio (zebrafish) ]

    Gene ID: 192303, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dcun1d2aprovided by ZNC
    Official Full Name
    DCN1, defective in cullin neddylation 1, domain containing 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020416-2
    See related
    Ensembl:ENSDARG00000040838 AllianceGenome:ZFIN:ZDB-GENE-020416-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb191; rp42-pen; zgc:77887
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in protein neddylation. Predicted to be part of ubiquitin ligase complex. Is expressed in several structures, including adaxial cell; axis; lens; pectoral fin; and pharyngeal arch 3-7 skeleton. Orthologous to human DCUN1D2 (defective in cullin neddylation 1 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See dcun1d2a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (34938316..34945582, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (35129131..35136416, complement)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene UPF3A regulator of nonsense mediated mRNA decay Neighboring gene cell division cycle 16 homolog (S. cerevisiae) Neighboring gene transcription factor Dp-1, a Neighboring gene methyltransferase 21C, AARS1 lysine b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Chaperone-Mediated Autophagy in the Light of Evolution: Insight from Fish. Lescat L, et al. Mol Biol Evol, 2020 Oct 1. PMID 32437540
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DCN1-like protein 2a
    Names
    rp42 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205538.1 → NP_991101.1  DCN1-like protein 2a

      See identical proteins and their annotated locations for NP_991101.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065884
      UniProtKB/TrEMBL
      A0A8M1PCT2, Q6P007
      Related
      ENSDARP00000059860.5, ENSDART00000059861.7
      Conserved Domains (2) summary
      cd14412
      Location:2 → 48
      UBA_DCNL2; UBA-like domain found in DCN1-like protein 2 (DCNL2) and similar proteins
      pfam03556
      Location:136 → 246
      Cullin_binding; Cullin binding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      34938316..34945582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167810.5 → XP_005167867.1  DCN1-like protein 2a isoform X1

      See identical proteins and their annotated locations for XP_005167867.1

      UniProtKB/TrEMBL
      A0A8M9Q4G8
      Related
      ENSDARP00000123371.1, ENSDART00000131908.3
      Conserved Domains (2) summary
      pfam03556
      Location:121 → 231
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 33
      UBA_like_SF; UBA domain-like superfamily

    2. XM_005167811.5 → XP_005167868.1  DCN1-like protein 2a isoform X1

      See identical proteins and their annotated locations for XP_005167868.1

      UniProtKB/TrEMBL
      A0A8M9Q4G8
      Related
      ENSDARP00000121805.1, ENSDART00000136812.2
      Conserved Domains (2) summary
      pfam03556
      Location:121 → 231
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 33
      UBA_like_SF; UBA domain-like superfamily

    3. XM_021478598.2 → XP_021334273.1  DCN1-like protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q4G8
      Conserved Domains (2) summary
      pfam03556
      Location:121 → 231
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 33
      UBA_like_SF; UBA domain-like superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394760.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      228987..236287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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