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    taf6l TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor [ Danio rerio (zebrafish) ]

    Gene ID: 557363, updated on 2-Nov-2024

    Summary

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    Official Symbol
    taf6lprovided by ZNC
    Official Full Name
    TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6789
    See related
    Ensembl:ENSDARG00000079684 AllianceGenome:ZFIN:ZDB-GENE-030131-6789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa05b10; wu:fa05b10
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly. Predicted to act upstream of or within transcription initiation at RNA polymerase II promoter. Predicted to be located in membrane and nucleus. Predicted to be part of SAGA complex; SLIK (SAGA-like) complex; and transcription factor TFIID complex. Orthologous to human TAF6L (TATA-box binding protein associated factor 6 like). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See taf6l in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (17953641..17970923)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (17701660..17718950)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 family, member 2 Neighboring gene cysteine three histidine 1 Neighboring gene potassium channel, subfamily K, member 7 Neighboring gene EH domain binding protein 1-like 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function. Manesia JK, et al. Stem Cells Dev, 2017 Apr 15. PMID 27958775, Free PMC Article
    2. Cd248a and Cd248b in zebrafish participate in innate immune responses. Li X, et al. Front Immunol, 2022. PMID 36119065, Free PMC Article
    3. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199722.1 → NP_001186651.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

      See identical proteins and their annotated locations for NP_001186651.1

      Status: VALIDATED

      Source sequence(s)
      AL954709
      UniProtKB/TrEMBL
      A0A8M1NVI8, E7FEV1
      Related
      ENSDARP00000100182.2, ENSDART00000113120.4
      Conserved Domains (2) summary
      cd08050
      Location:13 → 322
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl21461
      Location:316 → 380
      Globin_like; Globin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      17953641..17970923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477550.2 → XP_021333225.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

      UniProtKB/TrEMBL
      A0A8M9QH20
      Conserved Domains (2) summary
      cd08050
      Location:1 → 268
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
      cl21461
      Location:262 → 326
      Globin_like; Globin-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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