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    arpc4 actin related protein 2/3 complex, subunit 4 [ Danio rerio (zebrafish) ]

    Gene ID: 114456, updated on 2-Nov-2024

    Summary

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    Official Symbol
    arpc4provided by ZNC
    Official Full Name
    actin related protein 2/3 complex, subunit 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010724-9
    See related
    Ensembl:ENSDARG00000054063 AllianceGenome:ZFIN:ZDB-GENE-010724-9
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa07b12; zgc:77932; wu:fa07b12
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be part of Arp2/3 protein complex. Orthologous to human ARPC4 (actin related protein 2/3 complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See arpc4 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40762429..40768654, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40764893..40771118, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase, transmembrane b Neighboring gene myosin, heavy chain b Neighboring gene si:ch211-157b11.8 Neighboring gene H1.10 linker histone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Liu TX, et al. Dev Cell, 2003 Dec. PMID 14667412
    2. Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish. Peña OA, et al. Front Cell Dev Biol, 2021. PMID 34589480, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 2/3 complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205537.1 → NP_991100.1  actin-related protein 2/3 complex subunit 4

      See identical proteins and their annotated locations for NP_991100.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065899
      UniProtKB/TrEMBL
      A8E5F5, Q6NZZ2
      Related
      ENSDARP00000155849.1, ENSDART00000184668.1
      Conserved Domains (1) summary
      pfam05856
      Location:1 → 166
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      40762429..40768654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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