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    phf14 PHD finger protein 14 [ Danio rerio (zebrafish) ]

    Gene ID: 555505, updated on 2-Nov-2024

    Summary

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    Official Symbol
    phf14provided by ZNC
    Official Full Name
    PHD finger protein 14provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1796
    See related
    Ensembl:ENSDARG00000061458 AllianceGenome:ZFIN:ZDB-GENE-030131-1796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb80h09; wu:fb80h09; zgc:153464; si:dkeyp-89d7.1
    Summary
    Enables histone binding activity; histone reader activity; and zinc ion binding activity. Predicted to be involved in several processes, including mesenchymal cell proliferation involved in lung development; negative regulation of mesenchymal cell proliferation involved in lung development; and negative regulation of platelet-derived growth factor receptor-alpha signaling pathway. Predicted to be located in nucleus. Orthologous to human PHF14 (PHD finger protein 14). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See phf14 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (38168006..38327975)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (38580876..38740613)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene neurexophilin 1 Neighboring gene uncharacterized LOC137488449 Neighboring gene uncharacterized LOC137488540 Neighboring gene small ArfGAP2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14. Zheng S, et al. Nucleic Acids Res, 2021 Sep 7. PMID 34365506, Free PMC Article
    2. The genetic program of oocytes can be modified in vivo in the zebrafish ovary. Wu X, et al. J Mol Cell Biol, 2018 Dec 1. PMID 30060229
    3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14.
      Title: Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC153464

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mesenchymal cell proliferation involved in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mesenchymal cell proliferation involved in lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423773.1 → NP_001410702.1  PHD finger protein 14

      Status: VALIDATED

      Source sequence(s)
      BM860695, BX276085, BX530058, EB848970, EH445934, GFIL01022304
      UniProtKB/Swiss-Prot
      A0A286Y9D1
      UniProtKB/TrEMBL
      A0A8M2B6J6
      Related
      ENSDARP00000143778.1, ENSDART00000177759.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      38168006..38327975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159688.5 → XP_005159745.1  PHD finger protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B6H0
      Conserved Domains (4) summary
      cd15561
      Location:287 → 343
      PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15562
      Location:694 → 743
      PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15563
      Location:833 → 881
      PHD3_PHF14; PHD finger 3 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15674
      Location:351 → 464
      ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

    2. XM_005159689.5 → XP_005159746.1  PHD finger protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IK67, A0A8M2B6E7
      Related
      ENSDARP00000136231.1, ENSDART00000160756.2
      Conserved Domains (3) summary
      cd15561
      Location:287 → 343
      PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15562
      Location:694 → 743
      PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15674
      Location:351 → 464
      ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

    3. XM_005159690.5 → XP_005159747.1  PHD finger protein 14 isoform X4

      UniProtKB/TrEMBL
      A0A8M2B6B3
      Conserved Domains (3) summary
      cd15561
      Location:287 → 343
      PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15562
      Location:694 → 743
      PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15674
      Location:351 → 464
      ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

    4. XM_068215132.1 → XP_068071233.1  PHD finger protein 14 isoform X3

    5. XM_009294355.4 → XP_009292630.1  PHD finger protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A8M3B3P0
      Conserved Domains (3) summary
      cd15561
      Location:287 → 343
      PHD1_PHF14; PHD finger 1 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15562
      Location:694 → 743
      PHD2_PHF14; PHD finger 2 found in PHD finger protein 14 (PHF14) and similar proteins
      cd15674
      Location:351 → 464
      ePHD_PHF14; Extended PHD finger found in PHD finger protein 14 (PHF14) and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001044787.2: Suppressed sequence

      Description
      NM_001044787.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A286Y9D1.1 GenPept UniProtKB/Swiss-Prot:A0A286Y9D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials