mhc1uka major histocompatibility complex class I UKA [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mhc1ukaprovided by ZNC
Official Full Name: major histocompatibility complex class I UKAprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060825-152
See related: Ensembl:ENSDARG00000092731 AllianceGenome:ZFIN:ZDB-GENE-060825-152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: UCA; mhc1uca; Dare-UCA; zgc:153728; si:ch73-213j4.4
Summary: Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including MR1 (major histocompatibility complex, class I-related). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 19

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (7043620..7051516)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (7124693..7132571)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: major histocompatibility complex class I UKA

Names: MHC class I antigen UKA; major histocompatibility complex class I UCA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045460.1 → NP_001038925.1 major histocompatibility complex class I UKA isoform 2 precursor

See identical proteins and their annotated locations for NP_001038925.1

Status: PROVISIONAL

Source sequence(s)

BC122401

UniProtKB/TrEMBL

Q0P3X2

Conserved Domains (2) summary

cd07698
Location:197 → 293

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

cl08246
Location:19 → 193

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_001423392.2 → NP_001410321.2 major histocompatibility complex class I UKA isoform 1 precursor

Status: VALIDATED

Source sequence(s)

FP085393

Related

ENSDARP00000117273.2, ENSDART00000133954.4