lyve1a lymphatic vessel endothelial hyaluronic receptor 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lyve1aprovided by ZNC
Official Full Name: lymphatic vessel endothelial hyaluronic receptor 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-138
See related: Ensembl:ENSDARG00000075833 AllianceGenome:ZFIN:ZDB-GENE-031118-138
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zeh0104; hm:zeh0104; si:dkeyp-104h2.3
Summary: Enables hyaluronic acid binding activity. Acts upstream of or within lymphangiogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in posterior cardinal vein. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (66822442..66833588)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (66598794..66609940)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hyaluronic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronic acid binding	IDA Inferred from Direct Assay more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymphangiogenesis	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lymphatic vessel endothelial hyaluronic acid receptor 1a

Names: lymphatic vessel endothelial hyaluronan receptor 1; zmp:0000000782

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309475.1 → NP_001296404.1 lymphatic vessel endothelial hyaluronic acid receptor 1a precursor

Status: VALIDATED

Source sequence(s)

CU468622, EH432880

UniProtKB/TrEMBL

A0A8M1P6N1, F1R2G7

Related

ENSDARP00000104347.2, ENSDART00000112109.5

Conserved Domains (1) summary

cl02612
Location:41 → 174

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...