eed embryonic ectoderm development [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eedprovided by ZNC
Official Full Name: embryonic ectoderm developmentprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-287
See related: Ensembl:ENSDARG00000099640 AllianceGenome:ZFIN:ZDB-GENE-050417-287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:112509
Summary: Predicted to contribute to nucleosome binding activity. Acts upstream of or within several processes, including digestive system development; liver development; and regulation of glial cell differentiation. Predicted to be located in nucleus. Predicted to be part of ESC/E(Z) complex. Is expressed in several structures, including brain; head; liver; pectoral fin bud; and pleuroperitoneal region. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (27688..34330)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (27688..34330)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish.
Title: Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

z6416 (e-PCR), detects polymorphism
- UniSTS:204883

G40434 (e-PCR)
- UniSTS:68439

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: polycomb protein eed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017766.2 → NP_001017766.2 polycomb protein eed

Status: VALIDATED

Source sequence(s)

CU651657, EH444530, EH462224, EH467674, EH542978

UniProtKB/TrEMBL

A0A8M1N587

Related

ENSDARP00000131820.1, ENSDART00000162928.1

Conserved Domains (3) summary

COG2319
Location:79 → 440

WD40; WD40 repeat [General function prediction only]

sd00039
Location:96 → 140

7WD40; WD40 repeat [structural motif]

cl02567
Location:155 → 438

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...