got2a glutamic-oxaloacetic transaminase 2a, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: got2aprovided by ZNC
Official Full Name: glutamic-oxaloacetic transaminase 2a, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2703
See related: Ensembl:ENSDARG00000041068 AllianceGenome:ZFIN:ZDB-GENE-040426-2703
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: got2; mAspAT; zgc:66329
Summary: Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate catabolic process. Predicted to act upstream of or within amino acid metabolic process and biosynthetic process. Predicted to be located in mitochondrial matrix and plasma membrane. Predicted to be active in mitochondrion. Is expressed in intestine. Used to study developmental and epileptic encephalopathy 82 and early infantile epileptic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 82. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (21178854..21188742, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (21189788..21199676, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

AI496862 (e-PCR)
- UniSTS:206395

fb64g01 (e-PCR)
- UniSTS:189056

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables kynurenine-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: aspartate aminotransferase, mitochondrial

Names: glutamate oxaloacetate transaminase 2a; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); glutamic-oxaloacetic transaminase 2a, mitochondrial (aspartate aminotransferase 2); kynurenine aminotransferase 4; kynurenine aminotransferase IV; kynurenine--oxoglutarate transaminase 4; kynurenine--oxoglutarate transaminase IV; transaminase A

NP_998544.1

EC 2.6.1.1

EC 2.6.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.