boc BOC cell adhesion associated, oncogene regulated [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bocprovided by ZNC
Official Full Name: BOC cell adhesion associated, oncogene regulatedprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6560
See related: Ensembl:ENSDARG00000074335 AllianceGenome:ZFIN:ZDB-GENE-030131-6560
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fa16d03; wu:fa16d03
Summary: Enables identical protein binding activity. Involved in smoothened signaling pathway involved in ventral spinal cord patterning. Acts upstream of or within regulation of smoothened signaling pathway and retinal ganglion cell axon guidance. Predicted to be located in membrane. Predicted to be active in axon. Is expressed in several structures, including anterior neural keel; nervous system; neural plate; neural rod; and neural tube. Orthologous to human BOC (BOC cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (21207277..21258945, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (21062858..21114526, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.
Title: Mutations in cdon and boc affect trunk neural crest cell migration and slow-twitch muscle development in zebrafish.
Zebrafish spinal cord oligodendrocyte formation requires boc function.
Title: Zebrafish spinal cord oligodendrocyte formation requires boc function.
The study reveals a role for Boc in ventral CNS cells that receive high levels of Hh and uncovers previously unknown roles for Boc in vertebrate embryogenesis.
Title: Brother of cdo (umleitung) is cell-autonomously required for Hedgehog-mediated ventral CNS patterning in the zebrafish.
This study indicate that boc is an axon-guidance molecule playing a fundamental role in pathfinding during the early patterning of the axon scaffold in the embryonic vertebrate brain.
Title: BOC, brother of CDO, is a dorsoventral axon-guidance molecule in the embryonic vertebrate brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal ganglion cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway involved in ventral spinal cord patterning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smoothened signaling pathway involved in ventral spinal cord patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: brother of CDO

Names: uml; umleitung

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005393.1 → NP_001005393.1 brother of CDO precursor

See identical proteins and their annotated locations for NP_001005393.1

Status: PROVISIONAL

Source sequence(s)

AF461120

UniProtKB/TrEMBL

Q8UVD6

Related

ENSDARP00000098383.3, ENSDART00000111025.4

Conserved Domains (7) summary

smart00408
Location:342 → 403

IGc2; Immunoglobulin C-2 Type

smart00410
Location:242 → 315

IG_like; Immunoglobulin like

cd00063
Location:579 → 674

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:328 → 411

I-set; Immunoglobulin I-set domain

pfam13895
Location:40 → 128

Ig_2; Immunoglobulin domain

pfam16625
Location:422 → 463

ISET-FN3_linker; Unstructured linking region I-set and fnIII on Brother of CDO

cl11960
Location:243 → 316

Ig; Immunoglobulin domain