aldh8a1 aldehyde dehydrogenase 8 family, member A1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aldh8a1provided by ZNC
Official Full Name: aldehyde dehydrogenase 8 family, member A1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-3
See related: Ensembl:ENSDARG00000036776 AllianceGenome:ZFIN:ZDB-GENE-040912-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi34g05; zgc:92068; wu:fi34g05
Summary: Predicted to enable retinal dehydrogenase activity. Acts upstream of or within liver development. Predicted to be located in cytoplasm. Is expressed in intestinal bulb; intestinal bulb epithelium; intestine; and liver. Orthologous to human ALDH8A1 (aldehyde dehydrogenase 8 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (31752604..31763708, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (31826073..31837177, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNA Expression of Raldh4 during zebrafish early development (Raldh4).
Title: Expressions of Raldh3 and Raldh4 during zebrafish early development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminomuconate-semialdehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables retinal dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-kynurenine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-aminomuconic semialdehyde dehydrogenase

Names: Raldh4; aldehyde dehydrogenase family 8 member A1

NP_001004540.1

EC 1.2.1.32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004540.1 → NP_001004540.1 2-aminomuconic semialdehyde dehydrogenase

See identical proteins and their annotated locations for NP_001004540.1

Status: PROVISIONAL

Source sequence(s)

BC081581

UniProtKB/Swiss-Prot

Q66I21

UniProtKB/TrEMBL

A9YD19

Related

ENSDARP00000053398.4, ENSDART00000053399.5

Conserved Domains (1) summary

cd07093
Location:27 → 485

ALDH_F8_HMSADH; Human aldehyde dehydrogenase family 8 member A1-like