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    magt1 magnesium transporter 1 [ Danio rerio (zebrafish) ]

    Gene ID: 324944, updated on 12-Sep-2024

    Summary

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    Official Symbol
    magt1provided by ZNC
    Official Full Name
    magnesium transporter 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3667
    See related
    Ensembl:ENSDARG00000058062 AllianceGenome:ZFIN:ZDB-GENE-030131-3667
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc49b02; zgc:56218; wu:fc49b02
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity. Acts upstream of or within magnesium ion transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia; congenital disorder of glycosylation Icc; and non-syndromic X-linked intellectual disability. Orthologous to human MAGT1 (magnesium transporter 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See magt1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (12370375..12391446, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (12064361..12085432, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487569 Neighboring gene gap junction protein beta 1b Neighboring gene THO complex 2 Neighboring gene glutamate receptor, ionotropic, AMPA 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Zhou H, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19717468, Free PMC Article
    2. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Trinh le A, et al. Genes Dev, 2011 Nov 1. PMID 22056673, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within magnesium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    magnesium transporter protein 1
    Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
    oligosaccharyl transferase subunit MAGT1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199700.1 → NP_955994.1  magnesium transporter protein 1 precursor

      See identical proteins and their annotated locations for NP_955994.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046002
      UniProtKB/Swiss-Prot
      Q7ZV50
      Related
      ENSDARP00000075309.4, ENSDART00000080864.6
      Conserved Domains (2) summary
      cd02961
      Location:47 → 140
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      pfam04756
      Location:160 → 310
      OST3_OST6; OST3 / OST6 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      12370375..12391446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZV50.1 GenPept UniProtKB/Swiss-Prot:Q7ZV50

    Gene LinkOut

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