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    hexa hexosaminidase A (alpha polypeptide) [ Danio rerio (zebrafish) ]

    Gene ID: 550460, updated on 2-Nov-2024

    Summary

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    Official Symbol
    hexaprovided by ZNC
    Official Full Name
    hexosaminidase A (alpha polypeptide)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-283
    See related
    Ensembl:ENSDARG00000052113 AllianceGenome:ZFIN:ZDB-GENE-050417-283
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:112084
    Summary
    Predicted to enable beta-N-acetylhexosaminidase activity. Predicted to be involved in N-glycan processing; ganglioside catabolic process; and glycosaminoglycan metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in lysosome and membrane. Is expressed in several structures, including axis; lens placode; optic vesicle; polster; and visual system. Human ortholog(s) of this gene implicated in Tay-Sachs disease. Orthologous to human HEXA (hexosaminidase subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See hexa in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (22216760..22241312)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (22119212..22143764)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Neighboring gene plakophilin 3a Neighboring gene nuclear receptor subfamily 2, group E, member 3 Neighboring gene stomatin (EPB72)-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. Berg RD, et al. Cell, 2016 Mar 24. PMID 27015311, Free PMC Article
    2. The lysosomal GPCR-like protein GPR137B regulates Rag and mTORC1 localization and activity. Gan L, et al. Nat Cell Biol, 2019 May. PMID 31036939, Free PMC Article
    3. The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex. Meireles AM, et al. Dev Cell, 2018 Nov 5. PMID 30399334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC173657

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables beta-N-acetylhexosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-N-acetylhexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ganglioside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycosaminoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta-hexosaminidase subunit alpha
    NP_001017763.1
    XP_021326163.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017763.1 → NP_001017763.1  beta-hexosaminidase subunit alpha precursor

      See identical proteins and their annotated locations for NP_001017763.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093192
      UniProtKB/TrEMBL
      Q567F4
      Related
      ENSDARP00000051290.4, ENSDART00000051291.5
      Conserved Domains (2) summary
      cd06562
      Location:172 → 514
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:30 → 150
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      22216760..22241312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470488.2 → XP_021326163.1  beta-hexosaminidase subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M9PGT9
      Conserved Domains (2) summary
      cd06562
      Location:172 → 514
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:30 → 150
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395203.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      53359..77911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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