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    melk maternal embryonic leucine zipper kinase [ Danio rerio (zebrafish) ]

    Gene ID: 30724, updated on 14-Nov-2024

    Summary

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    Official Symbol
    melkprovided by ZNC
    Official Full Name
    maternal embryonic leucine zipper kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990603-5
    See related
    Ensembl:ENSDARG00000030759 AllianceGenome:ZFIN:ZDB-GENE-990603-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb71b01; fe01f04; wu:fb71b01; wu:fe01f04
    Summary
    Predicted to enable calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in hemopoiesis. Acts upstream of or within erythrocyte development and regulation of heart contraction. Predicted to be located in cell cortex. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; immature eye; nervous system; pleuroperitoneal region; and proliferative region. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See melk in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (21861387..21881818, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (21168450..21188881, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene paired box 5 Neighboring gene uncharacterized LOC137495488 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene lysine (K)-specific demethylase 4C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells. Saito R, et al. Cancer Sci, 2012 Jan. PMID 21923749, Free PMC Article
    2. Melk-like kinase plays a role in hematopoiesis in the zebra fish. Saito R, et al. Mol Cell Biol, 2005 Aug. PMID 16024803, Free PMC Article
    3. Normalization of RNA-sequencing data from samples with varying mRNA levels. Aanes H, et al. PLoS One, 2014. PMID 24586560, Free PMC Article
    4. Rmrp Mutation Disrupts Chondrogenesis and Bone Ossification in Zebrafish Model of Cartilage-Hair Hypoplasia via Enhanced Wnt/β-Catenin Signaling. Sun X, et al. J Bone Miner Res, 2019 Nov. PMID 31237961
    5. Toxicological assessment of trace β-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. Yin X, et al. PLoS One, 2014. PMID 25062015, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maternal embryonic leucine zipper kinase
    Names
    protein kinase PK38
    zMelk
    NP_996771.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_206888.2 → NP_996771.2  maternal embryonic leucine zipper kinase

      See identical proteins and their annotated locations for NP_996771.2

      Status: PROVISIONAL

      Source sequence(s)
      BC050520
      UniProtKB/Swiss-Prot
      F1QGZ6, Q7ZU72, Q7ZZN5
      Related
      ENSDARP00000047727.6, ENSDART00000047728.7
      Conserved Domains (4) summary
      cd12198
      Location:577 → 671
      MELK_C; C-terminal kinase associated domain 1 (KA1) of Maternal embryonic leucine zipper kinase
      smart00220
      Location:13 → 264
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14341
      Location:283 → 334
      UBA_MELK; UBA domain found in maternal embryonic leucine zipper kinase (MELK) and similar proteins
      cd14078
      Location:9 → 264
      STKc_MELK; Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      21861387..21881818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QGZ6.1 GenPept UniProtKB/Swiss-Prot:F1QGZ6

    Gene LinkOut

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