nlgn1 neuroligin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nlgn1provided by ZNC
Official Full Name: neuroligin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-090918-1
See related: Ensembl:ENSDARG00000077710 AllianceGenome:ZFIN:ZDB-GENE-090918-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable neurexin family protein binding activity and signaling receptor activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in membrane. Predicted to be active in cell surface and postsynaptic specialization membrane. Is expressed in several structures, including brain; cardiovascular system; eye; gonad; and swim bladder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (9560292..10328549, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (9577284..10128069, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coinjection of low doses of morpholinos for beta-neurexin 1a and neuroligin 1 together or in combination with morpholinos targeting the -heparin--binding isoforms of vascular endothelial growth factor A recapitulates the observed abnormalities
Title: The synaptic proteins β-neurexin and neuroligin synergize with extracellular matrix-binding vascular endothelial growth factor a during zebrafish vascular development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables neurexin family protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuroligin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.