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    mark2a MAP/microtubule affinity-regulating kinase 2a [ Danio rerio (zebrafish) ]

    Gene ID: 562231, updated on 14-Nov-2024

    Summary

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    Official Symbol
    mark2aprovided by ZNC
    Official Full Name
    MAP/microtubule affinity-regulating kinase 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4145
    See related
    Ensembl:ENSDARG00000079905 AllianceGenome:ZFIN:ZDB-GENE-030131-4145
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc75f05; wu:fc75f05; si:dkey-175m17.8
    Summary
    Predicted to enable protein serine/threonine kinase activity and tau-protein kinase activity. Predicted to be involved in intracellular signal transduction and microtubule cytoskeleton organization. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mark2a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (27203752..27273735, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (27167032..27237070, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene zgc:110782 Neighboring gene zgc:77262 Neighboring gene uncharacterized LOC137488820 Neighboring gene uncharacterized LOC101883290 Neighboring gene si:dkey-175m17.7 Neighboring gene si:dkey-175m17.6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. Li F, et al. PLoS One, 2016. PMID 27046191, Free PMC Article
    2. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Rakshambikai R, et al. J Bioinform Comput Biol, 2014 Feb. PMID 24467753
    3. Phylogenetic, syntenic, and tissue expression analysis of slc22 genes in zebrafish (Danio rerio). Mihaljevic I, et al. BMC Genomics, 2016 Aug 12. PMID 27519738, Free PMC Article
    4. Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Nolte H, et al. Proteomics, 2015 Feb. PMID 25504979
    5. The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. Lang I, et al. Int J Mol Sci, 2020 Aug 9. PMID 32784920, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MARK2
    XP_005161424.1
    XP_005161428.1
    XP_005161429.1
    XP_009293774.1
    XP_009293775.1
    XP_009293776.1
    XP_009293777.1
    XP_009293778.1
    XP_009293779.1
    XP_009293780.1
    XP_009293781.1
    XP_009293784.1
    XP_009293785.1
    XP_009293786.1
    XP_021324768.1
    XP_068072162.1
    XP_068072163.1
    XP_068072164.1
    XP_068072165.1
    XP_068072166.1
    XP_068072167.1
    XP_068072168.1
    XP_068072169.1
    XP_068072170.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      27203752..27273735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216067.1 → XP_068072168.1  serine/threonine-protein kinase MARK2 isoform X20

    2. XM_009295511.4 → XP_009293786.1  serine/threonine-protein kinase MARK2 isoform X16

      UniProtKB/TrEMBL
      A0A8M3B4V9
      Conserved Domains (4) summary
      cd12201
      Location:624 → 722
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:313 → 354
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 295
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    3. XM_068216064.1 → XP_068072165.1  serine/threonine-protein kinase MARK2 isoform X14

    4. XM_009295510.4 → XP_009293785.1  serine/threonine-protein kinase MARK2 isoform X24

      UniProtKB/TrEMBL
      A0A8M3ALN0
      Related
      ENSDARP00000040753.7, ENSDART00000040754.8
      Conserved Domains (4) summary
      cd12201
      Location:661 → 759
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:313 → 354
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 295
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    5. XM_005161372.5 → XP_005161429.1  serine/threonine-protein kinase MARK2 isoform X7

      UniProtKB/TrEMBL
      A0A8M2B8K8
      Related
      ENSDARP00000143274.2, ENSDART00000175009.2
      Conserved Domains (4) summary
      cd12201
      Location:670 → 768
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:313 → 354
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 295
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    6. XM_068216062.1 → XP_068072163.1  serine/threonine-protein kinase MARK2 isoform X11

    7. XM_005161367.5 → XP_005161424.1  serine/threonine-protein kinase MARK2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B8C0
      Conserved Domains (4) summary
      cd12201
      Location:682 → 780
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:313 → 366
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 295
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    8. XM_068216066.1 → XP_068072167.1  serine/threonine-protein kinase MARK2 isoform X19

    9. XM_068216063.1 → XP_068072164.1  serine/threonine-protein kinase MARK2 isoform X13

    10. XM_068216061.1 → XP_068072162.1  serine/threonine-protein kinase MARK2 isoform X9

    11. XM_005161371.5 → XP_005161428.1  serine/threonine-protein kinase MARK2 isoform X6

      UniProtKB/TrEMBL
      A0A8M2B8F7
      Conserved Domains (4) summary
      cd12201
      Location:671 → 769
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 355
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    12. XM_068216065.1 → XP_068072166.1  serine/threonine-protein kinase MARK2 isoform X18

    13. XM_009295509.4 → XP_009293784.1  serine/threonine-protein kinase MARK2 isoform X17

      UniProtKB/TrEMBL
      A0A8M3AU26
      Conserved Domains (4) summary
      cd12201
      Location:624 → 722
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    14. XM_009295506.4 → XP_009293781.1  serine/threonine-protein kinase MARK2 isoform X15

      UniProtKB/TrEMBL
      A0A8M3AX09, E9QHU0
      Related
      ENSDARP00000118845.1, ENSDART00000143239.3
      Conserved Domains (4) summary
      cd12201
      Location:637 → 735
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    15. XM_009295504.4 → XP_009293779.1  serine/threonine-protein kinase MARK2 isoform X10

      UniProtKB/TrEMBL
      A0A8M3B4V5
      Conserved Domains (4) summary
      cd12201
      Location:661 → 759
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    16. XM_009295502.4 → XP_009293777.1  serine/threonine-protein kinase MARK2 isoform X5

      UniProtKB/TrEMBL
      A0A8M3AU19
      Conserved Domains (4) summary
      cd12201
      Location:673 → 771
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    17. XM_009295501.4 → XP_009293776.1  serine/threonine-protein kinase MARK2 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AX04
      Conserved Domains (4) summary
      cd12201
      Location:674 → 772
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    18. XM_009295503.4 → XP_009293778.1  serine/threonine-protein kinase MARK2 isoform X8

      UniProtKB/TrEMBL
      A0A8M3ALM5
      Conserved Domains (4) summary
      cd12201
      Location:670 → 768
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    19. XM_009295500.4 → XP_009293775.1  serine/threonine-protein kinase MARK2 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AMC2
      Conserved Domains (4) summary
      cd12201
      Location:682 → 780
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    20. XM_009295499.4 → XP_009293774.1  serine/threonine-protein kinase MARK2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B4V1
      Conserved Domains (4) summary
      cd12201
      Location:683 → 781
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:44 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    21. XM_009295505.4 → XP_009293780.1  serine/threonine-protein kinase MARK2 isoform X12

      UniProtKB/TrEMBL
      A0A8M3AMD0
      Conserved Domains (4) summary
      cd12201
      Location:654 → 752
      MARK2_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 2
      smart00220
      Location:15 → 267
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14406
      Location:285 → 338
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:15 → 267
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    22. XM_068216069.1 → XP_068072170.1  serine/threonine-protein kinase MARK2 isoform X23

    23. XM_068216068.1 → XP_068072169.1  serine/threonine-protein kinase MARK2 isoform X22

    24. XM_021469093.2 → XP_021324768.1  serine/threonine-protein kinase MARK2 isoform X21

      UniProtKB/TrEMBL
      A0A8M9PDA8
      Conserved Domains (2) summary
      cd14406
      Location:314 → 367
      UBA_MARK2; UBA domain found in serine/threonine-protein kinase MARK2 and similar proteins
      cd14072
      Location:44 → 296
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    Nucleotide Protein Strain
    Heading Accession and Version

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