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    zfr zinc finger RNA binding protein [ Danio rerio (zebrafish) ]

    Gene ID: 321659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zfrprovided by ZNC
    Official Full Name
    zinc finger RNA binding proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-378
    See related
    Ensembl:ENSDARG00000027109 AllianceGenome:ZFIN:ZDB-GENE-030131-378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hnrpa1; zgc:66235; zgc:66403; wu:fb25b08
    Summary
    Predicted to enable double-stranded RNA binding activity and single-stranded RNA binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in telencephalon. Orthologous to human ZFR (zinc finger RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zfr in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41124736..41142791, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (40524583..40542671, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene golgi phosphoprotein 3a Neighboring gene myotubularin related protein 12 Neighboring gene SUB1 regulator of transcription b Neighboring gene uncharacterized LOC137495520

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cell Mus musculus embryos. Doğanlı C, et al. DNA Cell Biol, 2010 Dec. PMID 21091219
    2. Transcriptome analysis of zebrafish embryogenesis using microarrays. Mathavan S, et al. PLoS Genet, 2005 Aug. PMID 16132083, Free PMC Article
    3. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In D. rerio, Zfr mRNA expression was highest in unfertilized eggs and declines throughout development.
      Title: Early developmental expression of Mus musculus zinc finger RNA-binding protein compared to orthologs in Caenorhabditis elegans and Danio rerio and subcellular localization of Mus musculus and Caenorhabditis elegans zinc finger RNA-binding protein in 2-cell Mus musculus embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199558.2 → NP_955852.2  zinc finger RNA-binding protein

      Status: VALIDATED

      Source sequence(s)
      BX470118
      UniProtKB/Swiss-Prot
      Q6PCR6
      UniProtKB/TrEMBL
      A0A8M1PD13, A2BGG2
      Related
      ENSDARP00000069275.4, ENSDART00000074789.6
      Conserved Domains (3) summary
      smart00572
      Location:784 → 1037
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      smart00451
      Location:575 → 606
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:578 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      41124736..41142791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068221096.1 → XP_068077197.1  zinc finger RNA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q6PCR6
      Related
      ENSDART00000130579.3

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394602.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      189463..207518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCR6.2 GenPept UniProtKB/Swiss-Prot:Q6PCR6

    Gene LinkOut

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