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    aurka aurora kinase A [ Danio rerio (zebrafish) ]

    Gene ID: 445246, updated on 2-Nov-2024

    Summary

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    Official Symbol
    aurkaprovided by ZNC
    Official Full Name
    aurora kinase Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040801-161
    See related
    Ensembl:ENSDARG00000012485 AllianceGenome:ZFIN:ZDB-GENE-040801-161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb37c10; fc02c02; wu:fb37c10; wu:fc02c02; zgc:100912
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within mitotic cell cycle. Predicted to be located in cytoplasm and microtubule. Predicted to be part of chromosome passenger complex. Predicted to be active in kinetochore; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See aurka in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (60125055..60139655)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (60130132..60144746)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene SLAIN motif family, member 1b Neighboring gene prostate transmembrane protein, androgen induced 1 Neighboring gene phosphoenolpyruvate carboxykinase 1 (soluble) Neighboring gene PRELI domain containing 3 Neighboring gene solute carrier family 32 member 1 Neighboring gene uncharacterized LOC137496034

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ALKBH3-dependent m(1)A demethylation of Aurora A mRNA inhibits ciliogenesis. Kuang W, et al. Cell Discov, 2022 Mar 11. PMID 35277482, Free PMC Article
    2. Subcellular drug targeting illuminates local kinase action. Bucko PJ, et al. Elife, 2019 Dec 24. PMID 31872801, Free PMC Article
    3. Rosmarinic acid plays a protective role in the embryogenesis of zebrafish exposed to food colours through its influence on aurora kinase A level. Swarnalatha Y, et al. Biomed Pharmacother, 2017 May. PMID 28320082
    4. CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation. Ki SM, et al. EMBO Rep, 2020 Feb 5. PMID 31885126, Free PMC Article
    5. Transcriptome Profiling Reveals Enhanced Mitochondrial Activity as a Cold Adaptive Strategy to Hypothermia in Zebrafish Muscle. Cahill T, et al. Cells, 2023 May 11. PMID 37408201, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within meiotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic centrosome separation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aurora kinase A
    Names
    serine/threonine-protein kinase 6
    NP_001003640.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003640.2 → NP_001003640.1  aurora kinase A

      See identical proteins and their annotated locations for NP_001003640.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078304
      UniProtKB/TrEMBL
      Q6DBZ4
      Related
      ENSDARP00000021253.3, ENSDART00000008224.5
      Conserved Domains (2) summary
      smart00220
      Location:138 → 388
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14116
      Location:132 → 389
      STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      60125055..60139655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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