prmt8b protein arginine methyltransferase 8b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prmt8bprovided by ZNC
Official Full Name: protein arginine methyltransferase 8bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7791
See related: Ensembl:ENSDARG00000045760 AllianceGenome:ZFIN:ZDB-GENE-030131-7791
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zfL3; prmt8; HRMT1L3; hrmt1l4; wu:fj34f03
Summary: Enables arginine N-methyltransferase activity. Acts upstream of or within dendrite morphogenesis and midbrain-hindbrain boundary development. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain; eye; and somite. Orthologous to human PRMT8 (protein arginine methyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (11146618..11165638, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (11149132..11166818, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

prmt8 may play important roles non-overlapping with prmt1 in embryonic and neural development depending on its specific N-terminus.
Title: The critical role of protein arginine methyltransferase prmt8 in zebrafish embryonic and neural development is non-redundant with its paralogue prmt1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables S-adenosylmethionine-dependent methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables arginine N-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables arginine N-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N asymmetric methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine omega-N asymmetric methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-arginine omega-N asymmetric methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-arginine omega-N monomethyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine omega-N monomethyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chordate embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within midbrain-hindbrain boundary development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-arginine methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-arginine methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein arginine N-methyltransferase 8-B

Names: HMT1 hnRNP methyltransferase-like 4; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4; protein arginine N-methyltransferase 8; protein arginine methyltransferase 8

NP_001038507.1

EC 2.1.1.319

XP_005164711.1

EC 2.1.1.319

XP_005164712.1

EC 2.1.1.319

XP_021330726.1

EC 2.1.1.319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045042.1 → NP_001038507.1 protein arginine N-methyltransferase 8-B

See identical proteins and their annotated locations for NP_001038507.1

Status: PROVISIONAL

Source sequence(s)

BX784029

UniProtKB/TrEMBL

A0A2R8QJ87

Related

ENSDARP00000153084.1, ENSDART00000188854.1

Conserved Domains (1) summary

cd02440
Location:55 → 155

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

11146618..11165638 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021475051.2 → XP_021330726.1 protein arginine N-methyltransferase 8-B isoform X3

UniProtKB/TrEMBL

A0A8M9Q5Y0

Conserved Domains (1) summary

cd02440
Location:139 → 239

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_005164655.5 → XP_005164712.1 protein arginine N-methyltransferase 8-B isoform X2

See identical proteins and their annotated locations for XP_005164712.1

UniProtKB/Swiss-Prot

Q5RGQ2

Related

ENSDARP00000059488.6, ENSDART00000059489.7

Conserved Domains (1) summary

cd02440
Location:140 → 240

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_005164654.5 → XP_005164711.1 protein arginine N-methyltransferase 8-B isoform X1

UniProtKB/TrEMBL

A0A2R8Q6G4, A0A8M2BBS0

Related

ENSDARP00000148688.1, ENSDART00000193393.1

Conserved Domains (1) summary

cd02440
Location:141 → 241

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...