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    calb1 calbindin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 100001650, updated on 2-Nov-2024

    Summary

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    Official Symbol
    calb1provided by ZNC
    Official Full Name
    calbindin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8107
    See related
    Ensembl:ENSDARG00000031598 AllianceGenome:ZFIN:ZDB-GENE-030131-8107
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj53a05; wu:fj53a05
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of long-term synaptic potentiation and regulation of presynaptic cytosolic calcium ion concentration. Predicted to be active in several cellular components, including cytosol; dendritic spine; and terminal bouton. Is expressed in brain. Orthologous to human CALB1 (calbindin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See calb1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (36765934..36798648, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (36812050..36845028, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene collagen, type VI, alpha 4a Neighboring gene phosphoinositide-3-kinase, regulatory subunit 4 Neighboring gene 2,4-dienoyl CoA reductase 1, mitochondrial Neighboring gene purine nucleoside phosphorylase 4b Neighboring gene tyrosyl-DNA phosphodiesterase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Synaptic transmission from horizontal cells to cones is impaired by loss of connexin hemichannels. Klaassen LJ, et al. PLoS Biol, 2011 Jul. PMID 21811399, Free PMC Article
    2. Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae. Wang X, et al. Front Pharmacol, 2021. PMID 34925021, Free PMC Article
    3. Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Wu M, et al. Aquat Toxicol, 2017 Nov. PMID 28992598
    4. Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Yokoi H, et al. Dev Biol, 2009 May 1. PMID 19210963, Free PMC Article
    5. A spinal organ of proprioception for integrated motor action feedback. Picton LD, et al. Neuron, 2021 Apr 7. PMID 33577748

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vitamin D binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of long-term synaptic potentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of presynaptic cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calbindin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      36765934..36798648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001341568.6 → XP_001341604.1  calbindin

      UniProtKB/TrEMBL
      A0A8M1PUZ3, E9QJF8
      Related
      ENSDARP00000115794.1, ENSDART00000145697.2
      Conserved Domains (3) summary
      PTZ00184
      Location:14 → 170
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:101 → 170
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:151 → 210
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein Strain
    Heading Accession and Version

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