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    ppp1r13bb protein phosphatase 1, regulatory subunit 13Bb [ Danio rerio (zebrafish) ]

    Gene ID: 557278, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ppp1r13bbprovided by ZNC
    Official Full Name
    protein phosphatase 1, regulatory subunit 13Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4327
    See related
    Ensembl:ENSDARG00000009142 AllianceGenome:ZFIN:ZDB-GENE-030131-4327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc90h02; ppp1r13b; wu:fc90h02; si:ch211-253p18.1
    Summary
    Predicted to enable p53 binding activity. Predicted to act upstream of or within apoptotic process; negative regulation of cell cycle; and regulation of apoptotic process. Predicted to be active in nucleus. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ppp1r13bb in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (20730780..20813752)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (20831096..20914079)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene reticulon 1b Neighboring gene ATP synthase membrane subunit j Neighboring gene RD3 like Neighboring gene creatine kinase, brain b Neighboring gene BRF1 general transcription factor IIIB subunit b Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of differentially expressed genes between cloned and zygote-developing zebrafish (Danio rerio) embryos at the dome stage using suppression subtractive hybridization. Luo D, et al. Biol Reprod, 2009 Apr. PMID 19092113
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1, regulatory subunit 13Bb
    Names
    apoptosis-stimulating protein of p53
    protein phosphatase 1, regulatory (inhibitor) subunit 13B
    protein phosphatase 1, regulatory (inhibitor) subunit 13Bb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044824.2 → NP_001038289.2  protein phosphatase 1, regulatory subunit 13Bb

      See identical proteins and their annotated locations for NP_001038289.2

      Status: PROVISIONAL

      Source sequence(s)
      BC139881
      UniProtKB/TrEMBL
      A5D6T8
      Related
      ENSDARP00000047661.5, ENSDART00000047662.8
      Conserved Domains (6) summary
      TIGR02473
      Location:152 → 305
      flagell_FliJ; flagellar export protein FliJ
      cd11954
      Location:1001 → 1057
      SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
      cd00204
      Location:865 → 988
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam02050
      Location:225 → 327
      FliJ; Flagellar FliJ protein
      pfam12796
      Location:871 → 962
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:871 → 897
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      20730780..20813752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294642.4 → XP_009292917.1  protein phosphatase 1, regulatory subunit 13Bb isoform X3

      UniProtKB/TrEMBL
      A0A0R4IUG8, A0A8M3B416
      Related
      ENSDARP00000138021.1, ENSDART00000165224.2
      Conserved Domains (6) summary
      TIGR02473
      Location:152 → 305
      flagell_FliJ; flagellar export protein FliJ
      cd11954
      Location:1051 → 1107
      SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
      cd00204
      Location:915 → 1038
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam02050
      Location:225 → 327
      FliJ; Flagellar FliJ protein
      pfam12796
      Location:921 → 1012
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:921 → 947
      ANK; ANK repeat [structural motif]

    2. XM_068215465.1 → XP_068071566.1  protein phosphatase 1, regulatory subunit 13Bb isoform X6

    3. XM_009294640.4 → XP_009292915.1  protein phosphatase 1, regulatory subunit 13Bb isoform X1

      UniProtKB/TrEMBL
      A0A8M3AT48
      Conserved Domains (6) summary
      TIGR02473
      Location:196 → 349
      flagell_FliJ; flagellar export protein FliJ
      cd11954
      Location:1095 → 1151
      SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
      cd00204
      Location:959 → 1082
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:965 → 1056
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:965 → 991
      ANK; ANK repeat [structural motif]
      cl09111
      Location:250 → 369
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    4. XM_005160501.5 → XP_005160558.1  protein phosphatase 1, regulatory subunit 13Bb isoform X4

      UniProtKB/TrEMBL
      A0A2R8QDZ7, A0A8M2B7B9
      Related
      ENSDARP00000151938.1, ENSDART00000181524.1
      Conserved Domains (6) summary
      TIGR02473
      Location:196 → 349
      flagell_FliJ; flagellar export protein FliJ
      cd11954
      Location:1045 → 1101
      SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
      cd00204
      Location:909 → 1032
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:915 → 1006
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:915 → 941
      ANK; ANK repeat [structural motif]
      cl09111
      Location:250 → 369
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    5. XM_009294641.4 → XP_009292916.1  protein phosphatase 1, regulatory subunit 13Bb isoform X2

      UniProtKB/TrEMBL
      A0A8M3AKR4
      Conserved Domains (6) summary
      TIGR02473
      Location:196 → 349
      flagell_FliJ; flagellar export protein FliJ
      cd11954
      Location:1087 → 1143
      SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
      cd00204
      Location:951 → 1074
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:957 → 1048
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:957 → 983
      ANK; ANK repeat [structural motif]
      cl09111
      Location:250 → 377
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    6. XM_068215464.1 → XP_068071565.1  protein phosphatase 1, regulatory subunit 13Bb isoform X5

    7. XM_009294643.4 → XP_009292918.1  protein phosphatase 1, regulatory subunit 13Bb isoform X7

      UniProtKB/TrEMBL
      A0A8M3ALG4
      Conserved Domains (7) summary
      TIGR02473
      Location:84 → 237
      flagell_FliJ; flagellar export protein FliJ
      cd11954
      Location:983 → 1039
      SH3_ASPP1; Src Homology 3 domain of Apoptosis Stimulating of p53 protein 1
      cd00204
      Location:847 → 970
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam02050
      Location:157 → 259
      FliJ; Flagellar FliJ protein
      pfam12796
      Location:853 → 944
      Ank_2; Ankyrin repeats (3 copies)
      pfam15456
      Location:105 → 177
      Uds1; Up-regulated During Septation
      sd00045
      Location:853 → 879
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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