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    nras NRAS proto-oncogene, GTPase [ Danio rerio (zebrafish) ]

    Gene ID: 30380, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nrasprovided by ZNC
    Official Full Name
    NRAS proto-oncogene, GTPaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-166
    See related
    Ensembl:ENSDARG00000038225 AllianceGenome:ZFIN:ZDB-GENE-990415-166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj99a10; zras-b1; wu:fj99a10; zgc:100761; etID18709.8
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nras in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (11114757..11131696, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (11077052..11093991, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene DENN/MADD domain containing 2C Neighboring gene adenosine monophosphate deaminase 1 (isoform M) Neighboring gene ankyrin repeat and SOCS box containing 13b Neighboring gene pleckstrin homology domain containing A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing, and embryonic expression of an N-ras proto-oncogene isolated from an enriched zebrafish (Danio rerio) cDNA library. Cheng R, et al. Mol Mar Biol Biotechnol, 1997 Mar. PMID 9116869
    2. Genetically Encoded Aminocoumarin Lysine for Optical Control of Protein-Nucleotide Interactions in Zebrafish Embryos. Brown W, et al. ACS Chem Biol, 2023 Jun 16. PMID 37272594, Free PMC Article
    3. Oncogenic NRAS cooperates with p53 loss to generate melanoma in zebrafish. Dovey M, et al. Zebrafish, 2009 Dec. PMID 19954345, Free PMC Article
    4. p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1. Plaster N, et al. Cell Death Differ, 2006 Feb. PMID 16096653
    5. K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis. Liu L, et al. PLoS One, 2008 Aug 6. PMID 18682746, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase NRas
    Names
    N-ras oncogene p21
    neuroblastoma RAS viral (v-ras) oncogene homolog
    transforming protein N-Ras
    NP_571220.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131145.2 → NP_571220.2  GTPase NRas

      Status: VALIDATED

      Source sequence(s)
      CT027601, CU928015, EH537868
      UniProtKB/Swiss-Prot
      P79737
      UniProtKB/TrEMBL
      A0A8M1PBE6, Q6DGD1
      Related
      ENSDARP00000055741.4, ENSDART00000055742.5
      Conserved Domains (1) summary
      cd04138
      Location:3 → 163
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      11114757..11131696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79737.1 GenPept UniProtKB/Swiss-Prot:P79737

    Gene LinkOut

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