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    cnbpa CCHC-type zinc finger, nucleic acid binding protein a [ Danio rerio (zebrafish) ]

    Gene ID: 326846, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cnbpaprovided by ZNC
    Official Full Name
    CCHC-type zinc finger, nucleic acid binding protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5045
    See related
    Ensembl:ENSDARG00000045776 AllianceGenome:ZFIN:ZDB-GENE-030131-5045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zff9; zCNBP; fe36b09; zgc:63625; wu:fe36b09
    Summary
    Enables chromatin binding activity and nucleic acid binding activity. Acts upstream of or within several processes, including neural crest cell fate specification; regulation of DNA-templated transcription; and skeletal system development. Predicted to be active in cytoplasm. Is expressed in several structures, including alar plate midbrain region; digestive system; immature eye; nervous system; and pectoral fin. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See cnbpa in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (4699148..4705240, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (4763275..4769367, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene IQ motif and Sec7 domain ArfGEF 1a Neighboring gene glycoprotein IX platelet Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase a Neighboring gene synapsin IIa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish cellular nucleic acid-binding protein: gene structure and developmental behaviour. Armas P, et al. Gene, 2004 Aug 4. PMID 15276211
    2. Proteasomal inhibition attenuates craniofacial malformations in a zebrafish model of Treacher Collins Syndrome. Rosas MG, et al. Biochem Pharmacol, 2019 May. PMID 30849304
    3. In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities. Lombardo VA, et al. FEBS J, 2007 Jan. PMID 17166179
    4. CNBP controls transcription by unfolding DNA G-quadruplex structures. David AP, et al. Nucleic Acids Res, 2019 Sep 5. PMID 31219592, Free PMC Article
    5. Zebrafish cnbp intron1 plays a fundamental role in controlling spatiotemporal gene expression during embryonic development. Weiner AM, et al. J Cell Biochem, 2009 Dec 15. PMID 19830785

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CNBP controls transcription by unfolding DNA G-quadruplex structures.
      Title: CNBP controls transcription by unfolding DNA G-quadruplex structures.
    2. Zebrafish cnbp intron1 plays a fundamental role in controlling spatiotemporal gene expression during embryonic development.
      Title: Zebrafish cnbp intron1 plays a fundamental role in controlling spatiotemporal gene expression during embryonic development.
    3. CNBP mediates neural crest cell expansion by controlling cell proliferation and cell survival during rostral head development.
      Title: CNBP mediates neural crest cell expansion by controlling cell proliferation and cell survival during rostral head development.
    4. phosphorylation might be a conserved post-translational modification that allows CNBP to perform a fine tune expression regulation of a group of target genes, during embryogenesis
      Title: In vitro embryonic developmental phosphorylation of the cellular nucleic acid binding protein by cAMP-dependent protein kinase, and its relevance for biochemical activities.
    5. Findings suggest that zCNBP is a strikingly conserved single-stranded nucleic acid-binding protein which might interact with maternal mRNA during its storage in the embryo cell cytoplasm.
      Title: Zebrafish cellular nucleic acid-binding protein: gene structure and developmental behaviour.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic viscerocranium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within head development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural crest formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CCHC-type zinc finger, nucleic acid binding protein a
    Names
    CNBP
    cellular nucleic acid binding protein
    zinc finger protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244736.1 → NP_001231665.1  CCHC-type zinc finger, nucleic acid binding protein a

      See identical proteins and their annotated locations for NP_001231665.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH501940, EH531056
      UniProtKB/TrEMBL
      A0A8M1NYR9, F1Q6Z5
      Conserved Domains (1) summary
      PTZ00368
      Location:40 → 157
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    2. NM_199749.2 → NP_956043.2  CCHC-type zinc finger, nucleic acid binding protein a

      See identical proteins and their annotated locations for NP_956043.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CU571070
      UniProtKB/TrEMBL
      A0A8M1NYR9, F1Q6Z5
      Related
      ENSDARP00000067292.4, ENSDART00000067293.6
      Conserved Domains (1) summary
      PTZ00368
      Location:40 → 157
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      4699148..4705240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170569.4 → XP_005170626.1  CCHC-type zinc finger, nucleic acid binding protein a isoform X1

      See identical proteins and their annotated locations for XP_005170626.1

      UniProtKB/TrEMBL
      A0A8M1NYR9, F1Q6Z5
      Related
      ENSDARP00000115441.1, ENSDART00000136399.3
      Conserved Domains (1) summary
      PTZ00368
      Location:40 → 157
      PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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