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    lrrn1 leucine rich repeat neuronal 1 [ Danio rerio (zebrafish) ]

    Gene ID: 568527, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lrrn1provided by ZNC
    Official Full Name
    leucine rich repeat neuronal 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071126-1
    See related
    Ensembl:ENSDARG00000060115 AllianceGenome:ZFIN:ZDB-GENE-071126-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Acts upstream of or within olfactory nerve formation and olfactory placode morphogenesis. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in basal plate midbrain region; hindbrain neural keel; nervous system; neural plate; and somite. Orthologous to human LRRN1 (leucine rich repeat neuronal 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lrrn1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (43076516..43092175, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (43078980..43094639, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 Neighboring gene glycerate kinase Neighboring gene T cell leukemia translocation altered Neighboring gene uncharacterized LOC108190497 Neighboring gene arginine vasopressin receptor 2b, tandem duplicate, 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A rapid and scalable method for selecting recombinant mouse monoclonal antibodies. Crosnier C, et al. BMC Biol, 2010 Jun 4. PMID 20525357, Free PMC Article
    2. Increased locomotor activity via regulation of GABAergic signalling in foxp2 mutant zebrafish-implications for neurodevelopmental disorders. Lüffe TM, et al. Transl Psychiatry, 2021 Oct 14. PMID 34650032, Free PMC Article
    3. The Transcriptome of the Zebrafish Embryo After Chemical Exposure: A Meta-Analysis. Schüttler A, et al. Toxicol Sci, 2017 Jun 1. PMID 28329862, Free PMC Article
    4. A cell surface interaction network of neural leucine-rich repeat receptors. Söllner C, et al. Genome Biol, 2009. PMID 19765300, Free PMC Article
    5. The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Panza P, et al. Neural Dev, 2015 Oct 22. PMID 26492970, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within olfactory nerve formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory placode morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat neuronal protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130694.1 → NP_001124166.1  leucine-rich repeat neuronal protein 1 precursor

      See identical proteins and their annotated locations for NP_001124166.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155656
      UniProtKB/TrEMBL
      A0A8M1NKY2, A9JRH0
      Related
      ENSDARP00000078824.3, ENSDART00000084389.5
      Conserved Domains (8) summary
      smart00060
      Location:532 → 601
      FN3; Fibronectin type 3 domain
      smart00082
      Location:372 → 414
      LRRCT; Leucine rich repeat C-terminal domain
      smart00410
      Location:433 → 517
      IG_like; Immunoglobulin like
      cd00116
      Location:86 → 276
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:340 → 353
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:98 → 121
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:97 → 156
      LRR_8; Leucine rich repeat
      cl11960
      Location:441 → 517
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      43076516..43092175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394663.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      24669..40328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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