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    brd9 bromodomain containing 9 [ Danio rerio (zebrafish) ]

    Gene ID: 393245, updated on 2-Nov-2024

    Summary

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    Official Symbol
    brd9provided by ZNC
    Official Full Name
    bromodomain containing 9provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060502-1
    See related
    Ensembl:ENSDARG00000017143 AllianceGenome:ZFIN:ZDB-GENE-060502-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55797
    Summary
    Predicted to enable lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Is expressed in brain and liver. Orthologous to human BRD9 (bromodomain containing 9). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See brd9 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (52926141..52966835, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (53038367..53079093, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene thyroid hormone receptor interactor 13 Neighboring gene NKD inhibitor of WNT signaling pathway 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of Nova-dependent splicing regulation in the brain. Jelen N, et al. PLoS Genet, 2007 Oct. PMID 17937501, Free PMC Article
    2. Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Wu Y, et al. Sci Rep, 2017 Jun 22. PMID 28642470, Free PMC Article
    3. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55797

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200275.1 → NP_956569.1  bromodomain-containing protein 9

      See identical proteins and their annotated locations for NP_956569.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049140
      UniProtKB/Swiss-Prot
      Q7ZUF2
      Related
      ENSDARP00000023970.6, ENSDART00000009256.9
      Conserved Domains (2) summary
      cd05513
      Location:170 → 267
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:306 → 537
      DUF3512; Domain of unknown function (DUF3512)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      52926141..52966835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170124.5 → XP_005170181.1  bromodomain-containing protein 9 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BHG3
      Conserved Domains (2) summary
      cd05513
      Location:170 → 267
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:305 → 536
      DUF3512; Domain of unknown function (DUF3512)

    2. XM_068213915.1 → XP_068070016.1  bromodomain-containing protein 9 isoform X4

    3. XM_021466643.2 → XP_021322318.1  bromodomain-containing protein 9 isoform X2

      UniProtKB/TrEMBL
      A0A8M9P7T6
      Conserved Domains (2) summary
      cd05513
      Location:170 → 267
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:329 → 540
      DUF3512; Domain of unknown function (DUF3512)

    4. XM_005170122.5 → XP_005170179.1  bromodomain-containing protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHF7
      Conserved Domains (2) summary
      cd05513
      Location:170 → 267
      Bromo_brd7_like; Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene ...
      pfam12024
      Location:326 → 557
      DUF3512; Domain of unknown function (DUF3512)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUF2.1 GenPept UniProtKB/Swiss-Prot:Q7ZUF2

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