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    ndrg4 NDRG family member 4 [ Danio rerio (zebrafish) ]

    Gene ID: 692305, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ndrg4provided by ZNC
    Official Full Name
    NDRG family member 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060512-226
    See related
    Ensembl:ENSDARG00000103937 AllianceGenome:ZFIN:ZDB-GENE-060512-226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136766; si:ch211-194m7.2
    Summary
    Acts upstream of or within cardiac muscle cell proliferation; clustering of voltage-gated sodium channels; and heart looping. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including basal plate midbrain region; cardiovascular system; gut; nervous system; and spinal cord neural tube. Orthologous to human NDRG4 (NDRG family member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ndrg4 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (13332280..13390072, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (13235775..13293715, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene si:ch211-194m7.8 Neighboring gene si:ch211-194m7.5 Neighboring gene GINS complex subunit 3 Neighboring gene zinc and ring finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential expression and hypoxia-mediated regulation of the N-myc downstream regulated gene family. Le N, et al. FASEB J, 2021 Nov. PMID 34665878, Free PMC Article
    2. Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes. Sedletcaia A, et al. Dev Dyn, 2011 Jun. PMID 21448936, Free PMC Article
    3. Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Lefebvre KA, et al. Toxicol Sci, 2009 Jan. PMID 18936300, Free PMC Article
    4. Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish. Fontenas L, et al. PLoS Genet, 2016 Nov. PMID 27902705, Free PMC Article
    5. Ndrg4 is required for normal myocyte proliferation during early cardiac development in zebrafish. Qu X, et al. Dev Biol, 2008 May 15. PMID 18407257, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within clustering of voltage-gated sodium channels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein NDRG4
    Names
    N-myc downstream regulated gene 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045173.2 → NP_001038638.1  protein NDRG4

      Status: VALIDATED

      Source sequence(s)
      AL772241, BC116615, DQ649010
      UniProtKB/TrEMBL
      A0A0R4ICQ1, A0A8M1NA46, Q1JPS5
      Related
      ENSDARP00000130451.1, ENSDART00000163735.2
      Conserved Domains (2) summary
      COG0596
      Location:62 → 285
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:8 → 290
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      13332280..13390072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163082.5 → XP_005163139.1  protein NDRG4 isoform X8

      See identical proteins and their annotated locations for XP_005163139.1

      UniProtKB/TrEMBL
      A0A8M2BA48, A6XCT1, Q1JPS5
      Related
      ENSDARP00000141868.1, ENSDART00000169119.2
      Conserved Domains (2) summary
      COG0596
      Location:62 → 285
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:8 → 290
      Ndr; Ndr family

    2. XM_068217414.1 → XP_068073515.1  protein NDRG4 isoform X2

    3. XM_005163081.5 → XP_005163138.1  protein NDRG4 isoform X7

      UniProtKB/TrEMBL
      A0A8M9P6H2, Q1JPS5
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 322
      Ndr; Ndr family

    4. XM_005163079.5 → XP_005163136.1  protein NDRG4 isoform X5

      See identical proteins and their annotated locations for XP_005163136.1

      UniProtKB/TrEMBL
      A0A8M2BA87, Q1JPS5
      Conserved Domains (2) summary
      COG0596
      Location:139 → 362
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:85 → 367
      Ndr; Ndr family

    5. XM_005163080.5 → XP_005163137.1  protein NDRG4 isoform X6

      UniProtKB/TrEMBL
      A0A8M2BA26, Q1JPS5
      Conserved Domains (2) summary
      COG0596
      Location:123 → 346
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:69 → 351
      Ndr; Ndr family

    6. XM_005163077.5 → XP_005163134.1  protein NDRG4 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BA44
      Conserved Domains (2) summary
      COG0596
      Location:168 → 391
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:114 → 396
      Ndr; Ndr family

    7. XM_021470527.2 → XP_021326202.1  protein NDRG4 isoform X7

      UniProtKB/TrEMBL
      A0A8M9P6H2, Q1JPS5
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 322
      Ndr; Ndr family

    8. XM_009297861.4 → XP_009296136.1  protein NDRG4 isoform X5

      See identical proteins and their annotated locations for XP_009296136.1

      UniProtKB/TrEMBL
      A0A8M2BA87, Q1JPS5
      Conserved Domains (2) summary
      COG0596
      Location:139 → 362
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:85 → 367
      Ndr; Ndr family

    9. XM_068217415.1 → XP_068073516.1  protein NDRG4 isoform X4

    10. XM_068217413.1 → XP_068073514.1  protein NDRG4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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