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    cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 393319, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cdc73provided by ZNC
    Official Full Name
    cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1309
    See related
    Ensembl:ENSDARG00000020201 AllianceGenome:ZFIN:ZDB-GENE-040426-1309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    hrpt2; zgc:63956
    Summary
    Predicted to enable RNA polymerase II complex binding activity. Involved in heart development. Acts upstream of or within erythrocyte differentiation; regulation of transcription elongation by RNA polymerase II; and spinal cord oligodendrocyte cell differentiation. Located in nucleus. Part of Cdc73/Paf1 complex. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdc73 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (11946544..12003164)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (12162945..12219565)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 3, phospholipase Neighboring gene Ro60, Y RNA binding protein Neighboring gene beta-1,3-galactosyltransferase 2 Neighboring gene potassium channel, subfamily T, member 2a Neighboring gene uncharacterized LOC137487672 Neighboring gene G protein-coupled receptor 158b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Antagonistic regulation of PAF1C and p-TEFb is required for oligodendrocyte differentiation. Kim S, et al. J Neurosci, 2012 Jun 13. PMID 22699901, Free PMC Article
    2. The PAF1 complex differentially regulates cardiomyocyte specification. Langenbacher AD, et al. Dev Biol, 2011 May 1. PMID 21338598, Free PMC Article
    3. The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors. Jurynec MJ, et al. Development, 2019 Dec 16. PMID 31784460, Free PMC Article
    4. Anti-apoptotic effects of IGF-I on mortality and dysmorphogenesis in tbx5-deficient zebrafish embryos. Tsai TC, et al. BMC Dev Biol, 2018 Mar 5. PMID 29506474, Free PMC Article
    5. Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Nolte H, et al. Proteomics, 2015 Feb. PMID 25504979

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC63956

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cdc73/Paf1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cdc73/Paf1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    parafibromin
    Names
    Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
    hyperparathyroidism 2 homolog
    sun
    sunrise

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291396.1 → NP_001278325.1  parafibromin isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      CT573433, FP017159
      UniProtKB/TrEMBL
      A0A8M1P0N2, X1WHN7
      Related
      ENSDARP00000129750.1, ENSDART00000157155.2
      Conserved Domains (2) summary
      pfam05179
      Location:356 → 519
      CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
      pfam16050
      Location:1 → 296
      CDC73_N; Paf1 complex subunit CDC73 N-terminal

    2. NM_200348.2 → NP_956642.1  parafibromin isoform 2

      See identical proteins and their annotated locations for NP_956642.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) extends past a splice site in the 3' coding region that is used in variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      CT573433, FP017159
      UniProtKB/TrEMBL
      B2GS66, Q7T3D4
      Related
      ENSDARP00000017639.6, ENSDART00000013607.9
      Conserved Domains (2) summary
      pfam05179
      Location:356 → 519
      CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
      pfam16050
      Location:1 → 296
      CDC73_N; Paf1 complex subunit CDC73 N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      11946544..12003164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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