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    ak2 adenylate kinase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 321793, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ak2provided by ZNC
    Official Full Name
    adenylate kinase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-512
    See related
    Ensembl:ENSDARG00000005926 AllianceGenome:ZFIN:ZDB-GENE-030131-512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb34f05; wu:fj80e03
    Summary
    Predicted to enable adenylate kinase activity. Acts upstream of or within hematopoietic stem cell differentiation and leukocyte differentiation. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Is expressed in head; hematopoietic system; intermediate cell mass of mesoderm; and otic vesicle. Used to study reticular dysgenesis. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ak2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (35418683..35428894, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (35831563..35841787, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 Neighboring gene ring finger protein 19B Neighboring gene anillin, actin binding protein Neighboring gene protein tyrosine phosphatase 4A2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. Pannicke U, et al. Nat Genet, 2009 Jan. PMID 19043417
    2. Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs. Sood R, et al. PLoS One, 2013. PMID 23451191, Free PMC Article
    3. Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress. Rissone A, et al. J Exp Med, 2015 Jul 27. PMID 26150473, Free PMC Article
    4. Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency. Iwanami N. Exp Hematol, 2014 Aug. PMID 24824573
    5. A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress. Rissone A, et al. Dis Model Mech, 2019 Dec 20. PMID 31727854, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ak2 is required for the correct development, survival and regeneration of sensory hair cells
      Title: A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress.
    2. Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
      Title: Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
    3. Knockdown of zebrafish ak2 also leads to aberrant leukocyte development, stressing the evolutionarily conserved role of AK2.
      Title: Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleobase-containing compound kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, phosphate group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ADP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leukocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 2, mitochondrial
    NP_997761.1
    XP_005159705.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212596.1 → NP_997761.1  adenylate kinase 2, mitochondrial

      See identical proteins and their annotated locations for NP_997761.1

      Status: PROVISIONAL

      Source sequence(s)
      BC053160
      UniProtKB/Swiss-Prot
      Q1L8L9, Q7T3D7
      Related
      ENSDARP00000010686.4, ENSDART00000003167.5
      Conserved Domains (2) summary
      PRK00279
      Location:19 → 231
      adk; adenylate kinase; Reviewed
      cd01428
      Location:19 → 221
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      35418683..35428894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159648.4 → XP_005159705.1  adenylate kinase 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005159705.1

      UniProtKB/Swiss-Prot
      Q1L8L9, Q7T3D7
      UniProtKB/TrEMBL
      A0A0F6PK88, A0A8M2B693
      Related
      ENSDARP00000131617.1, ENSDART00000169006.2
      Conserved Domains (2) summary
      PRK00279
      Location:19 → 231
      adk; adenylate kinase; Reviewed
      cd01428
      Location:19 → 221
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1L8L9.1 GenPept UniProtKB/Swiss-Prot:Q1L8L9

    Gene LinkOut

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