cnbpb CCHC-type zinc finger, nucleic acid binding protein b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cnbpbprovided by ZNC
Official Full Name: CCHC-type zinc finger, nucleic acid binding protein bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7782
See related: Ensembl:ENSDARG00000070922 AllianceGenome:ZFIN:ZDB-GENE-030131-7782
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cnbp; wu:fj34c03
Summary: Predicted to enable mRNA binding activity; single-stranded RNA binding activity; and translation regulator activity. Involved in positive regulation of innate immune response. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to several human genes including CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (491587..497755, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (465089..471257, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cnbp overexpression rescued the Treacher Collins Syndrome phenotype in a dose-dependent manner by a reactive oxygen species-cytoprotective action that prevented the redox-responsive genes' upregulation but did not normalize the synthesis of ribosomal RNAs.
Title: Cnbp ameliorates Treacher Collins Syndrome craniofacial anomalies through a pathway that involves redox-responsive genes.
Role for CNBP in transcriptional control of components of the Wnt signaling pathway, which might explain its requirement for proper craniofacial development.
Title: CNBP modulates the transcription of Wnt signaling pathway components.
CNBP up-regulates tbx2b and smarca5, and down-regulates wnt5b gene expression.
Title: Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development.
Cnbp loss-of-function adversely affects the formation and survival of craniofacial cartilaginous structures not only controlling the ratio of cell proliferation and apoptosis but also defining skeletogenic neural crest cell fate.
Title: Deciphering the cellular and molecular roles of cellular nucleic acid binding protein during cranial neural crest development.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: CCHC-type zinc finger, nucleic acid binding protein b

Names: zinc finger protein 9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001326405.1 → NP_001313334.1 CCHC-type zinc finger, nucleic acid binding protein b

Status: VALIDATED

Source sequence(s)

CR855375

UniProtKB/TrEMBL

A0A8M1P8Y4, E7FCQ0

Related

ENSDARP00000095293.4, ENSDART00000104520.7

Conserved Domains (2) summary

PTZ00368
Location:38 → 155

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

COG5222
Location:6 → 20

COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]