zbtb1 zinc finger and BTB domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: zbtb1provided by ZNC
Official Full Name: zinc finger and BTB domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041001-126
See related: Ensembl:ENSDARG00000023040 AllianceGenome:ZFIN:ZDB-GENE-041001-126
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-1h6.5
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in telencephalon. Orthologous to human ZBTB1 (zinc finger and BTB domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (27712714..27718374)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (27813624..27819284)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 1

Names: novel zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214797.1 → NP_999962.1 zinc finger and BTB domain-containing protein 1

See identical proteins and their annotated locations for NP_999962.1

Status: PROVISIONAL

Source sequence(s)

AY577006

UniProtKB/TrEMBL

Q6PUQ9

Related

ENSDARP00000021226.4, ENSDART00000008306.6

Conserved Domains (4) summary

smart00225
Location:25 → 121

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00017
Location:544 → 564

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:14 → 118

BTB; BTB/POZ domain

pfam13465
Location:556 → 581

zf-H2C2_2; Zinc-finger double domain