ppa1a inorganic pyrophosphatase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ppa1aprovided by ZNC
Official Full Name: inorganic pyrophosphatase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1695
See related: Ensembl:ENSDARG00000099933 AllianceGenome:ZFIN:ZDB-GENE-040426-1695
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pp; zgc:73156
Summary: Predicted to enable inorganic diphosphate phosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in cytoplasm. Is expressed in epiphysis; retina; and retinal photoreceptor layer. Orthologous to human PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (48241822..48267595)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (48146441..48172214)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables inorganic diphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inorganic diphosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phosphate-containing compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphate-containing compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inorganic pyrophosphatase 2, mitochondrial

Names: pyrophosphatase (inorganic) 1a

NP_957027.1

EC 3.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200733.1 → NP_957027.1 inorganic pyrophosphatase 2, mitochondrial

See identical proteins and their annotated locations for NP_957027.1

Status: PROVISIONAL

Source sequence(s)

BC059512

UniProtKB/TrEMBL

Q6PC11

Related

ENSDARP00000135154.1, ENSDART00000168616.3

Conserved Domains (1) summary

cl00217
Location:2 → 242

pyrophosphatase; Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers.