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    rasl11b RAS-like, family 11, member B [ Danio rerio (zebrafish) ]

    Gene ID: 393109, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rasl11bprovided by ZNC
    Official Full Name
    RAS-like, family 11, member Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-793
    See related
    Ensembl:ENSDARG00000015611 AllianceGenome:ZFIN:ZDB-GENE-040426-793
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc21f04; zgc:55750; zgc:77749; wu:fc21f04
    Summary
    Predicted to enable G protein activity and GTP binding activity. Acts upstream of or within mesendoderm development. Is expressed in several structures, including axis; central nervous system; presumptive ectoderm; shield; and tail bud. Orthologous to human RASL11B (RAS like family 11 member B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rasl11b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (23022985..23026223, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (23123885..23127123, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene FIP1 like 1a (S. cerevisiae) Neighboring gene sec1 family domain containing 2 Neighboring gene uncharacterized LOC137488644 Neighboring gene uncharacterized LOC108180337 Neighboring gene uncharacterized LOC100536039 Neighboring gene small nucleolar RNA SNORA26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype. Pézeron G, et al. PLoS One, 2008 Jan 16. PMID 18197245, Free PMC Article
    2. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. Louro R, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033445
    3. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Taylor AM, et al. Exp Hematol, 2012 Mar. PMID 22120640, Free PMC Article
    4. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
    5. Full transcriptome analysis of early dorsoventral patterning in zebrafish. Fodor E, et al. PLoS One, 2013. PMID 23922899, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55750

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mesendoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-like protein family member 11B
    NP_956434.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200140.1 → NP_956434.1  ras-like protein family member 11B

      See identical proteins and their annotated locations for NP_956434.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044471
      UniProtKB/Swiss-Prot
      Q001T7, Q6P0U3, Q803I5
      Related
      ENSDARP00000003188.6, ENSDART00000015755.8
      Conserved Domains (2) summary
      smart00010
      Location:22 → 187
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd04146
      Location:25 → 193
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      23022985..23026223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P0U3.1 GenPept UniProtKB/Swiss-Prot:Q6P0U3

    Gene LinkOut

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