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    sh3gl2a SH3 domain containing GRB2 like 2a, endophilin A1 [ Danio rerio (zebrafish) ]

    Gene ID: 394091, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sh3gl2aprovided by ZNC
    Official Full Name
    SH3 domain containing GRB2 like 2a, endophilin A1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040121-3
    See related
    Ensembl:ENSDARG00000023600 AllianceGenome:ZFIN:ZDB-GENE-040121-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sh3gl2; zgc:55616
    Summary
    Predicted to be involved in synaptic vesicle uncoating. Predicted to be located in membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in nervous system; neural plate; neural tube; polster; and trigeminal placode. Orthologous to human SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See sh3gl2a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (26740719..26782513, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (26047005..26088799, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene si:dkey-25o16.4 Neighboring gene forkhead box E1 Neighboring gene centlein, centrosomal protein Neighboring gene basonuclin zinc finger protein 2 Neighboring gene uncharacterized LOC101882912

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish. Zhao Y, et al. Arterioscler Thromb Vasc Biol, 2013 Jun. PMID 23539215
    2. Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockwork. Tovin A, et al. PLoS Genet, 2012. PMID 23284293, Free PMC Article
    3. Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Teixeira CMM, et al. Zebrafish, 2019 Jun. PMID 31017557
    4. Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. White RJ, et al. Elife, 2022 Feb 17. PMID 35175196, Free PMC Article
    5. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55616

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in synaptic vesicle uncoating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain containing GRB2 like 2a, endophilin A1
    Names
    SH3-domain GRB2-like 2
    SH3-domain GRB2-like 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201116.1 → NP_957410.1  SH3 domain containing GRB2 like 2a, endophilin A1

      See identical proteins and their annotated locations for NP_957410.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044199
      UniProtKB/TrEMBL
      B2GPL2, Q803T6
      Related
      ENSDARP00000085044.3, ENSDART00000090611.6
      Conserved Domains (2) summary
      cd07613
      Location:25 → 247
      BAR_Endophilin_A1; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A1
      cd11803
      Location:288 → 342
      SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      26740719..26782513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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