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    ppp2r1bb protein phosphatase 2, regulatory subunit A, beta b [ Danio rerio (zebrafish) ]

    Gene ID: 449548, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ppp2r1bbprovided by ZNC
    Official Full Name
    protein phosphatase 2, regulatory subunit A, beta bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040927-20
    See related
    Ensembl:ENSDARG00000032430 AllianceGenome:ZFIN:ZDB-GENE-040927-20
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ppp2r1b; zgc:92493; tdsubc_2h3; wu:fa11a11; wu:fb38a08; ik:tdsubc_2h3; xx:tdsubc_2h3
    Summary
    Predicted to enable protein phosphatase regulator activity. Predicted to be involved in protein dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in female organism. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 36 and lung cancer. Orthologous to several human genes including PPP2R1B (protein phosphatase 2 scaffold subunit Abeta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ppp2r1bb in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (21744743..21772837)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (21809011..21837105)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene interleukin 4 induced 1 Neighboring gene NKAP domain containing 1 Neighboring gene uncharacterized LOC137487746 Neighboring gene salt-inducible kinase 2b Neighboring gene layilin b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Guenebeaud C, et al. Mol Cell, 2010 Dec 22. PMID 21172653
    2. WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. Hou CY, et al. Int J Mol Sci, 2022 Oct 11. PMID 36292952, Free PMC Article
    3. Proteomics of early zebrafish embryos. Link V, et al. BMC Dev Biol, 2006 Jan 13. PMID 16412219, Free PMC Article
    4. Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Hoffmann JL, et al. Aquat Toxicol, 2008 Apr 28. PMID 18339436
    5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic sister chromatid cohesion, centromeric IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    NP_001005590.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005590.1 → NP_001005590.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

      See identical proteins and their annotated locations for NP_001005590.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081658
      UniProtKB/TrEMBL
      A0A8M1N246, Q642H5
      Related
      ENSDARP00000017693.7, ENSDART00000016860.8
      Conserved Domains (4) summary
      pfam13513
      Location:179 → 227
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:207 → 303
      HEAT_2; HEAT repeats
      sd00044
      Location:245 → 269
      HEAT; HEAT repeat [structural motif]
      cl21454
      Location:396 → 454
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      21744743..21772837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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