thbs4b thrombospondin 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: thbs4bprovided by ZNC
Official Full Name: thrombospondin 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020708-4
See related: Ensembl:ENSDARG00000020072 AllianceGenome:ZFIN:ZDB-GENE-020708-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tsp4; thbs4; zgc:111910
Summary: Predicted to enable calcium ion binding activity and growth factor activity. Acts upstream of or within tendon development. Predicted to be located in extracellular space and sarcoplasmic reticulum. Predicted to be active in collagen-containing extracellular matrix. Is expressed in cranial cartilage; musculature system; notochord; pectoral fin; and trunk. Orthologous to human THBS4 (thrombospondin 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (5129523..5162687)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (4964958..4998122)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tsp4 functions as an ECM scaffold at myotendinous junctions, with potential therapeutic uses in tendon strengthening and repair
Title: Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions.

Submit: New GeneRIF Correction

General gene information

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Markers

G40807 (e-PCR)
- UniSTS:24068

z953 (e-PCR), detects polymorphism
- UniSTS:204772

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tendon development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within tendon development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: thrombospondin-4-B

Names: Tsp-4a; thbs4-B; thrombospondin 4; tsp4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173226.1 → NP_775333.1 thrombospondin-4-B precursor

See identical proteins and their annotated locations for NP_775333.1

Status: PROVISIONAL

Source sequence(s)

AY081009

UniProtKB/Swiss-Prot

Q8JGW0

Related

ENSDARP00000093348.4, ENSDART00000102572.5

Conserved Domains (8) summary

cd00054
Location:312 → 346

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

sd00001
Location:580 → 602

TSP3; TSP3 repeat_short [structural motif]

sd00002
Location:485 → 520

TSP3; TSP3 repeat_long [structural motif]

pfam02412
Location:486 → 520

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:734 → 931

TSP_C; Thrombospondin C-terminal region

cd16076
Location:225 → 264

TSPcc; coiled coil [structural motif]

cl13107
Location:222 → 265

TSPcc; Coiled coil region of thrombospondin

cl22861
Location:38 → 194

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...