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    lgals9l3 lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3 [ Danio rerio (zebrafish) ]

    Gene ID: 327284, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lgals9l3provided by ZNC
    Official Full Name
    lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-159
    See related
    Ensembl:ENSDARG00000041060 AllianceGenome:ZFIN:ZDB-GENE-040718-159
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Lgals9; lgals9l2; zgc:92326; wu:fd20c09; zgc:111833
    Summary
    Predicted to enable carbohydrate binding activity and galactoside binding activity. Predicted to be involved in negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of type II interferon production; and positive regulation of gene expression. Predicted to be active in cytosol and nucleus. Orthologous to human LGALS9 (galectin 9); LGALS9B (galectin 9B); and LGALS9C (galectin 9C). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See lgals9l3 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (31054200..31067665, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (31173459..31186924, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene lectin, galactoside-binding, soluble, 9 (galectin 9)-like 4 Neighboring gene lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1 Neighboring gene kinase suppressor of ras 1b Neighboring gene WD repeat and SOCS box containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, characterization and expression profiling of galectin-9 gene from Labeo rohita (Hamilton, 1822). Mushtaq Z, et al. Fish Shellfish Immunol, 2018 May. PMID 29477496
    2. Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Oosterhof N, et al. Cell Rep, 2018 Jul 31. PMID 30067976
    3. Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Zhou S, et al. Fish Shellfish Immunol, 2016 Feb. PMID 26767746
    4. Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Kolb J, et al. Nat Commun, 2023 Oct 26. PMID 37884489, Free PMC Article
    5. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactoside binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of type II interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3
    Names
    galactoside-binding soluble lectin 9
    galectin 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001817.2 → NP_001001817.2  lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3

      Status: VALIDATED

      Source sequence(s)
      AL928870
      Related
      ENSDARP00000060156.3, ENSDART00000060157.4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      31054200..31067665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213471.1 → XP_068069572.1  lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version

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