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    rnf128a ring finger protein 128a [ Danio rerio (zebrafish) ]

    Gene ID: 322325, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rnf128aprovided by ZNC
    Official Full Name
    ring finger protein 128aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1044
    See related
    Ensembl:ENSDARG00000016867 AllianceGenome:ZFIN:ZDB-GENE-030131-1044
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rnf128; zgc:77843; wu:fb57h05
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and late endosome. Is expressed in several structures, including EVL; digestive system; integument; periderm; and sensory system. Orthologous to several human genes including RNF128 (ring finger protein 128). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rnf128a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (23677430..23696874, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (23173630..23193074, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene gap junction protein, alpha 2 Neighboring gene TBC1 domain family member 8B Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 1 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The evolutionary fate of alternatively spliced homologous exons after gene duplication. Abascal F, et al. Genome Biol Evol, 2015 Apr 29. PMID 25931610, Free PMC Article
    2. Differential expression of neuroligin genes in the nervous system of zebrafish. Davey C, et al. Dev Dyn, 2010 Feb. PMID 20063411, Free PMC Article
    3. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF128a
    Names
    ring finger protein 128
    NP_997780.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212615.1 → NP_997780.1  E3 ubiquitin-protein ligase RNF128a precursor

      See identical proteins and their annotated locations for NP_997780.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067341
      UniProtKB/TrEMBL
      A0A8M1PH74, Q6NX00
      Related
      ENSDARP00000020552.4, ENSDART00000021462.6
      Conserved Domains (2) summary
      cd02122
      Location:38 → 172
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:256 → 297
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      23677430..23696874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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