mcl1a MCL1 apoptosis regulator, BCL2 family member a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mcl1aprovided by ZNC
Official Full Name: MCL1 apoptosis regulator, BCL2 family member aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000511-7
See related: Ensembl:ENSDARG00000009779 AllianceGenome:ZFIN:ZDB-GENE-000511-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zfMLP1; fb70a08; fb72f02; zfMcl-1a; wu:fb70a08; wu:fb72f02; zgc:109835
Summary: Enables protein heterodimerization activity. Acts upstream of or within several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of mitotic nuclear division; and tissue homeostasis. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in digestive system; eye; heart; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (348899..353231)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (348692..353024)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

transgenic overexpression of bcl2-like Bcl-xL-like protein 1 or zfMcl-1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Title: Imbalance in liver homeostasis leading to hyperplasia by overexpressing either one of the Bcl-2-related genes, zfBLP1 and zfMcl-1a.

Submit: New GeneRIF Correction

General gene information

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Markers

fb72f02 (e-PCR)
- UniSTS:187415

fb70a08.x1 (e-PCR)
- UniSTS:191010

fb72f02.x1 (e-PCR)
- UniSTS:191107

fb70a08 (e-PCR)
- UniSTS:187364

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chordate embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of mitotic nuclear division	IGI Inferred from Genetic Interaction more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within regulation of mitotic nuclear division	IGI Inferred from Genetic Interaction more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: induced myeloid leukemia cell differentiation protein Mcl-1a

Names: MCL1, BCL2 family apoptosis regulator a; myeloid cell leukemia 1a; myeloid cell leukemia sequence 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131599.1 → NP_571674.1 induced myeloid leukemia cell differentiation protein Mcl-1a

See identical proteins and their annotated locations for NP_571674.1

Status: PROVISIONAL

Source sequence(s)

AF302805

UniProtKB/TrEMBL

Q9I9N3

Related

ENSDARP00000098601.3, ENSDART00000114284.4

Conserved Domains (1) summary

cd06845
Location:86 → 223

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...