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    cyb5a cytochrome b5 type A (microsomal) [ Danio rerio (zebrafish) ]

    Gene ID: 406409, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cyb5aprovided by ZNC
    Official Full Name
    cytochrome b5 type A (microsomal)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2148
    See related
    Ensembl:ENSDARG00000098589 AllianceGenome:ZFIN:ZDB-GENE-040426-2148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cyb5; zgc:64123; wu:fb44a11
    Summary
    Enables heme binding activity and oxidoreductase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in intracellular membrane-bounded organelle and membrane. Is expressed in digestive system; head; immature eye; neural crest; and optic stalk. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to human CYB5A (cytochrome b5 type A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cyb5a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (2836307..2843039, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (2837562..2844354, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene phenylalanyl-tRNA synthetase 2, mitochondrial Neighboring gene LYR motif containing 4 Neighboring gene si:ch211-152c8.5 Neighboring gene si:ch211-152c8.2 Neighboring gene divergent protein kinase domain 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2. Pallan PS, et al. J Biol Chem, 2015 Feb 6. PMID 25533464, Free PMC Article
    2. The Zebrafish Cytochrome b(5)/Cytochrome b(5) Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b(5)/Cytochrome b(5) Reductases during Vertebrate Evolution. Amdahl MB, et al. Biochemistry, 2019 Jul 23. PMID 31257865, Free PMC Article
    3. Growth and Antioxidant-Related Effects of the Reestablished Ascorbic Acid Pathway in Zebrafish (Danio rerio) by Genomic Integration of L-Gulonolactone Oxidase From Cloudy Catshark (Scyliorhinus torazame). Shanaka KASN, et al. Front Physiol, 2021. PMID 34290620, Free PMC Article
    4. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Lupo G, et al. Proc Natl Acad Sci U S A, 2011 May 24. PMID 21555593, Free PMC Article
    5. Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. Lam SH, et al. PLoS Genet, 2008 Jul 11. PMID 18618001, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213135.2 → NP_998300.2  cytochrome b5

      Status: VALIDATED

      Source sequence(s)
      BX784022
      UniProtKB/TrEMBL
      A0A8M2BA27, A8WGS0, Q7T341
      Related
      ENSDARP00000140832.1, ENSDART00000165290.2
      Conserved Domains (1) summary
      pfam00173
      Location:15 → 87
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      2836307..2843039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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