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    tjp2b tight junction protein 2b (zona occludens 2) [ Danio rerio (zebrafish) ]

    Gene ID: 436639, updated on 14-Nov-2024

    Summary

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    Official Symbol
    tjp2bprovided by ZNC
    Official Full Name
    tight junction protein 2b (zona occludens 2)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-58
    See related
    Ensembl:ENSDARG00000023443 AllianceGenome:ZFIN:ZDB-GENE-040718-58
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb62b09; zgc:92094; wu:fb62b09
    Summary
    Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including digestive system; immature eye; nervous system; pronephros; and segmental plate. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to human TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See tjp2b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (11370187..11542848)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (11398418..11456135)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type I, beta b Neighboring gene frataxin Neighboring gene piercer of microtubule wall 1 Neighboring gene microRNA 126a Neighboring gene formin binding protein 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification, tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio. Kiener TK, et al. Gene Expr Patterns, 2007 Aug. PMID 17632043
    2. Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow. Schwayer C, et al. Cell, 2019 Oct 31. PMID 31675500
    3. Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Rödel CJ, et al. Circ Res, 2019 Oct 25. PMID 31495257
    4. Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Quint WH, et al. Sci Rep, 2023 Feb 3. PMID 36737489, Free PMC Article
    5. Temporal and spatial expression of tight junction genes during zebrafish pronephros development. McKee R, et al. Gene Expr Patterns, 2014 Nov. PMID 25460834, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio
      Title: Identification, tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tight junction protein ZO-2b
    Names
    tjp2.2
    zo-2.2
    zona occludens 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430967.1 → NP_001417896.1  tight junction protein ZO-2b isoform 1

      Status: VALIDATED

      Source sequence(s)
      CR361566, FQ377600

    2. NM_001430968.1 → NP_001417897.1  tight junction protein ZO-2b isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR361566, FQ377912

    3. NM_001430969.1 → NP_001417898.1  tight junction protein ZO-2b isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR361566, FQ377600
      Related
      ENSDARP00000086787.5, ENSDART00000092355.7

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      11370187..11542848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222917.1 → XP_068079018.1  tight junction protein ZO-2b isoform X1

    2. XM_068222919.1 → XP_068079020.1  tight junction protein ZO-2b isoform X3

    3. XM_068222923.1 → XP_068079024.1  tight junction protein ZO-2b isoform X7

    4. XM_068222921.1 → XP_068079022.1  tight junction protein ZO-2b isoform X5

    5. XM_068222924.1 → XP_068079025.1  tight junction protein ZO-2b isoform X8

      Related
      ENSDARP00000026529.9, ENSDART00000018739.10

    6. XM_068222920.1 → XP_068079021.1  tight junction protein ZO-2b isoform X4

    7. XM_068222918.1 → XP_068079019.1  tight junction protein ZO-2b isoform X2

    8. XM_068222922.1 → XP_068079023.1  tight junction protein ZO-2b isoform X6

      Related
      ENSDARP00000112709.1, ENSDART00000136184.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002366.1: Suppressed sequence

      Description
      NM_001002366.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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