abcb7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcb7provided by ZNC
Official Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 7provided by ZNC
Primary source: ZFIN:ZDB-GENE-050517-10
See related: Ensembl:ENSDARG00000062795 AllianceGenome:ZFIN:ZDB-GENE-050517-10
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fc20c02; wu:fc20c02
Summary: Predicted to enable ABC-type iron-sulfur cluster transporter activity. Involved in cellular detoxification and detoxification of zinc ion. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (10981678..11070161)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (10675682..10764137)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc20c02.x1 (e-PCR)
- UniSTS:192979

fc20c02.x1 (e-PCR)
- UniSTS:192980

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type iron-sulfur cluster transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detoxification of zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron-sulfur cluster assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in iron-sulfur cluster export from the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of reactive oxygen species biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heme biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: iron-sulfur clusters transporter ABCB7, mitochondrial

Names: ATP-binding cassette sub-family B member 7, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.