kbtbd8 kelch repeat and BTB (POZ) domain containing 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kbtbd8provided by ZNC
Official Full Name: kelch repeat and BTB (POZ) domain containing 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-030114-8
See related: Ensembl:ENSDARG00000070698 AllianceGenome:ZFIN:ZDB-GENE-030114-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb672; takrp; wu:fc57a10; zgc:152950
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in mesenchymal cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein monoubiquitination. Predicted to act upstream of or within regulation of translation. Predicted to be located in Golgi apparatus and spindle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adaxial cell; diencephalon; neural plate; primordial germ cell; and tail bud. Orthologous to human KBTBD8 (kelch repeat and BTB domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (16574715..16584257)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (16440080..16449622)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neural crest cell development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural crest formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kelch repeat and BTB domain-containing protein 8

Names: T-cell activation kelch repeat protein; TA-KRP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110030.1 → NP_001103500.1 kelch repeat and BTB domain-containing protein 8

See identical proteins and their annotated locations for NP_001103500.1

Status: PROVISIONAL

Source sequence(s)

BC154345

UniProtKB/Swiss-Prot

A8KC38, Q08CL3

UniProtKB/TrEMBL

B7ZVA9

Related

ENSDARP00000094847.4, ENSDART00000104072.6

Conserved Domains (5) summary

PHA03098
Location:40 → 516

PHA03098; kelch-like protein; Provisional

sd00038
Location:380 → 428

Kelch; KELCH repeat [structural motif]

pfam00651
Location:38 → 143

BTB; BTB/POZ domain

pfam01344
Location:379 → 428

Kelch_1; Kelch motif

pfam07707
Location:151 → 251

BACK; BTB And C-terminal Kelch