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    arpc5a actin related protein 2/3 complex, subunit 5A [ Danio rerio (zebrafish) ]

    Gene ID: 336504, updated on 2-Nov-2024

    Summary

    Official Symbol
    arpc5aprovided by ZNC
    Official Full Name
    actin related protein 2/3 complex, subunit 5Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8448
    See related
    Ensembl:ENSDARG00000039142 AllianceGenome:ZFIN:ZDB-GENE-030131-8448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arpc5; fb09c07; fb12b05; fc56c07; wu:fb09c07; wu:fb12b05; wu:fc56c07
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Predicted to act upstream of or within regulation of actin filament polymerization. Predicted to be located in actin cytoskeleton; cell projection; and nucleus. Predicted to be part of Arp2/3 protein complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ARPC5 (actin related protein 2/3 complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See arpc5a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (20967694..20975678)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21309639..21317616)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene prostaglandin-endoperoxide synthase 2a Neighboring gene phospholipase A2, group IVAa (cytosolic, calcium-dependent) Neighboring gene LYR motif containing 4 Neighboring gene neuritin 1b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2/3 complex subunit 5a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194378.4NP_919359.2  actin-related protein 2/3 complex subunit 5a

      See identical proteins and their annotated locations for NP_919359.2

      Status: VALIDATED

      Source sequence(s)
      CU570778, EH437356
      UniProtKB/TrEMBL
      B2GPC0, F6NNN5, Q803M7
      Related
      ENSDARP00000057173.5, ENSDART00000057174.7
      Conserved Domains (1) summary
      pfam04699
      Location:9148
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      20967694..20975678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223155.1XP_068079256.1  actin-related protein 2/3 complex subunit 5a isoform X1