etv4 ETS variant transcription factor 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: etv4provided by ZNC
Official Full Name: ETS variant transcription factor 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-71
See related: Ensembl:ENSDARG00000018303 AllianceGenome:ZFIN:ZDB-GENE-990415-71
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pea3
Summary: Enables sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within limb morphogenesis and pronephric nephron tubule epithelial cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including fin; head; mesoderm; nervous system; and neural keel. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (27536227..27568697)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (27444729..27477334)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

etv5a and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development
Title: Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development.
Pea3 and erm are required for zebrafish pronephrogenesis and can functionally complement each other, and the wt1a gene may be one of their downstream targets.
Title: Expression and function of the Ets transcription factor pea3 during formation of zebrafish pronephros.
Overlapping functions of pea3 ETS transcription factors in FGF signaling during zebrafish development are reported.
Title: Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development.

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General gene information

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Markers

fc19f01.x1 (e-PCR)
- UniSTS:187784

pea3 (e-PCR)
- UniSTS:187019

fc19f01.x1 (e-PCR)
- UniSTS:192934

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within limb morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ETS translocation variant 4

Names: ETS domain-containing transcription factor PEA3; etID309954.12; ets variant gene 4; polyomavirus enhancer activator 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131425.2 → NP_571500.2 ETS translocation variant 4

Status: VALIDATED

Source sequence(s)

AL833789, CT698283, EH579782, EH597159

UniProtKB/Swiss-Prot

O57586, Q9PUQ1

UniProtKB/TrEMBL

A0A8N1TV56

Related

ENSDARP00000016969.8, ENSDART00000013033.10

Conserved Domains (2) summary

smart00413
Location:349 → 433

ETS; erythroblast transformation specific domain

pfam04621
Location:5 → 348

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

27536227..27568697

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009306586.4 → XP_009304861.1 ETS translocation variant 4 isoform X1

UniProtKB/Swiss-Prot

O57586, Q9PUQ1

UniProtKB/TrEMBL

A0A8M3AY95

Conserved Domains (2) summary

smart00413
Location:350 → 434

ETS; erythroblast transformation specific domain

pfam04621
Location:5 → 349

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain